Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | CRHBP | P24387 | 1/20 | 0.39 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11164715 | 0.86 | ALDH1A1 (0.47) | LMNATSHRMAPTALDH1A1MEN1 | |
| SCHEMBL28376682 | 0.83 | LMNA (0.46) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL1241111 | 0.83 | ALDH1A1 (0.43) | LMNAMAPTALDH1A1TDP1CYP3A4 | |
| SCHEMBL28096698 | 0.83 | ADRB2 (0.46) | LMNATSHRMAPTALDH1A1MEN1 | |
| SCHEMBL16654106 | 0.82 | TSHR (0.51) | LMNATSHRMAPTALDH1A1MEN1 | |
| SCHEMBL14019279 | 0.81 | MET (0.42) | TSHRMAPTALDH1A1TDP1CYP3A4 | |
| SCHEMBL31352300 | 0.80 | KMT2A (0.57) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL8566920 | 0.80 | KMT2A (0.57) | LMNAMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL12798874 | 0.80 | TDP1 (0.62) | LMNATSHRMAPTALDH1A1MEN1 | |
| SCHEMBL9316221 | 0.79 | TSHR (0.56) | TSHRMAPTALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023169554-A1 | METHIONINE ADENOSINE TRANSFERASE INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF | 赛诺哈勃药业（成都）有限公司 | 2023-09-14 | — | — | WO | disclosed |
| US-7432379-B2 | Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists | ELAN PHARMACEUTICALS, INC. (US) | 2008-10-07 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |
| US-7417152-B2 | 4-bromo-5-(2-chloro-benzoylamino)-1H-pyrazole-3-carboxylic acid amide derivatives and related compounds as bradykinin B1 receptor antagonists for the treatment of inflammatory diseases | ELAN PHARMACEUTICALS, INC. (US) | 2008-08-26 | — | — | US | disclosed |