Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.48 |
| ▸ | MET | P08581 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 3/20 | 0.46 |
| ▸ | SRC | P12931 | 2/20 | 0.46 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MST1R | Q04912 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | DOT1L | Q8TEK3 | 2/20 | 0.43 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9800640 | 0.84 | MAPT (0.58) | ALDH1A1SCN9AMETKDRSRC | |
| SCHEMBL8736782 | 0.81 | ALDH1A1 (0.66) | ALDH1A1KDRAXLCYP3A4NPC1 | |
| SCHEMBL9800655 | 0.79 | KMT2A (0.64) | ALDH1A1SCN9ACYP3A4NPC1RAB9A | |
| SCHEMBL17164822 | 0.77 | NPC1 (0.61) | ALDH1A1METKDRSRCKIT | |
| SCHEMBL23063011 | 0.76 | PPARG (0.56) | ALDH1A1SCN9AMETKDRSRC | |
| SCHEMBL130884 | 0.75 | ALDH1A1 (1.00) | ALDH1A1NPC1POLBRAB9APDGFRB | |
| SCHEMBL11420788 | 0.74 | HTR2A (0.50) | ALDH1A1CHEK2POLBRAB9AHTR2A | |
| Ammonia Solution, Strong SCHEMBL27491586 | 0.74 | ALDH1A1 (0.96) | ALDH1A1NPC1POLBRAB9APDGFRB | |
| SCHEMBL20172428 | 0.74 | MPO (0.46) | ALDH1A1PPARGCHEK2POLBRAB9A | |
| SCHEMBL9800765 | 0.73 | ALDH1A1 (0.68) | ALDH1A1SCN9ACYP3A4PPARGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | MILLER SCOTT | 2008-10-30 | — | — | US | disclosed |
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | MILLER SCOTT | 2008-10-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080269265-A1 | Inhibition Of Raf Kinase Using Symmetrical And Unsymmetrical Substituted Diphenyl Ureas | BRAF, RAF1, MAP2K2 | ALDH1A1 2032/4885SCN9A 4537/4885MET 746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.