Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.69 |
| ▸ | ABCC8 | Q09428 | 3/20 | 0.69 |
| ▸ | KCNJ11 | Q14654 | 3/20 | 0.69 |
| ▸ | KCNJ8 | Q15842 | 3/20 | 0.69 |
| ▸ | PDK1 | Q15118 | 2/20 | 0.69 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.69 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.69 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.69 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.62 |
| ▸ | MEN1 | O00255 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 2/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83110 | 0.85 | L3MBTL1 (0.78) | LMNAPDK1PDK2PDK3PDK4 | |
| SCHEMBL7332862 | 0.83 | L3MBTL1 (0.76) | LMNAL3MBTL1ALDH1A1NPSR1RAB9A | |
| SCHEMBL7733701 | 0.82 | L3MBTL1 (1.00) | LMNAL3MBTL1ALDH1A1NPSR1RAB9A | |
| Zd-6169 SCHEMBL4261046 | 0.82 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| Zd-6169 SCHEMBL2123811 | 0.82 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL29037529 | 0.81 | L3MBTL1 (0.73) | LMNAPDK1PDK2PDK3PDK4 | |
| SCHEMBL28277461 | 0.81 | L3MBTL1 (0.73) | LMNAPDK1PDK2PDK3PDK4 | |
| SCHEMBL8866262 | 0.81 | ABCC9 (0.68) | LMNAABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL8866436 | 0.81 | ABCC9 (0.68) | LMNAABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL10050677 | 0.80 | ABCC9 (0.54) | LMNAABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| US-7432268-B2 | 17β-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases | SCHERING CORPORATION (US) | 2008-10-07 | — | — | US | disclosed |
| EP-1423381-B1 | 17BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 3 INHIBITORS FOR THE TREATMENT OF ANDROGEN DEPENDENT DISEASES | SCHERING CORP (US) | 2007-01-03 | — | — | EP | disclosed |