Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCC9 | O60706 | 7/20 | 0.68 |
| ▸ | ABCC8 | Q09428 | 7/20 | 0.68 |
| ▸ | KCNJ11 | Q14654 | 7/20 | 0.68 |
| ▸ | KCNJ8 | Q15842 | 7/20 | 0.68 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.68 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.68 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.68 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.68 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.51 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.51 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086870 | 0.88 | PDK1 (0.62) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL14086869 | 0.88 | PDK1 (0.62) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL27382549 | 0.87 | MEN1 (0.56) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL14033573 | 0.81 | LMNA (0.76) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| Zd-6169 SCHEMBL4261046 | 0.81 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| Zd-6169 SCHEMBL2123811 | 0.81 | ABCC9 (1.00) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL8865957 | 0.80 | ABCC9 (0.69) | ABCC9ABCC8KCNJ11KCNJ8ALDH1A1 | |
| SCHEMBL8866436 | 0.79 | ABCC9 (0.68) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL9459035 | 0.79 | ABCC9 (0.63) | ABCC9ABCC8KCNJ11KCNJ8PDK1 | |
| SCHEMBL8866235 | 0.77 | ABCC9 (0.73) | ABCC9ABCC8KCNJ11KCNJ8PDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684198-A | N-ARYL-2-HYDROXYPROPANAMIDES | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1997-11-04 | — | — | US | disclosed |
| US-5567735-A | CELL POTASSIUM CHANNEL MODULATOR FOR TREATING ASTHMA | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-22 | — | — | US | disclosed |
| US-5565477-A | TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-15 | — | — | US | disclosed |
| US-5565465-A | TREATMENT OF URINARY INCONTINENCE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1996-10-15 | — | — | US | disclosed |
| EP-0524781-B1 | Therapeutic amides | ZENECA LTD (GB) | 1996-03-27 | — | — | EP | disclosed |
| US-5474999-A | Useful in treatment of urinary incontinence | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-12-12 | — | — | US | disclosed |
| US-5382598-A | Therapeutic amides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-01-17 | — | — | US | disclosed |
| US-5272163-A | Therapeutic amides | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-12-21 | — | — | US | disclosed |
| EP-0524781-A1 | Therapeutic amides | ZENECA LIMITED (GB) | 1993-01-27 | — | — | EP | disclosed |