SCHEMBL1403558

SCHEMBL1403558

C=CC(=O)OC(C)N1C(=O)CCC1=O

nearest known ligand 0.36

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.36
SLC1A2 P43004 1/20 0.32
CHRM2 P08172 1/20 0.32
CHRM4 P08173 1/20 0.32
CHRM5 P08912 1/20 0.32
CHRM1 P11229 1/20 0.32
CHRM3 P20309 1/20 0.32
KMT2A Q03164 1/20 0.31
ATM Q13315 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21014820 0.95 TSHR (0.35) TSHR
SCHEMBL1147828 0.81 TSHR (0.33) TSHR
SCHEMBL4151214 0.80 LMNA (0.43) TSHRCHRM2CHRM4CHRM5CHRM1
SCHEMBL21243694 0.79 HCAR2 (0.43) SLC1A2CHRM2CHRM4CHRM5CHRM1
SCHEMBL2886147 0.79 ALDH1A1 (0.31) SLC1A2CHRM2CHRM4CHRM5CHRM1
SCHEMBL28034445 0.79 TSHR (0.36) TSHR
SCHEMBL11315322 0.78 TSHR (0.37) TSHRKMT2A
SCHEMBL19145897 0.78 LMNA (0.38) TSHRCHRM2CHRM4CHRM5CHRM1
SCHEMBL782188 0.77 SMN1; SMN2 (0.36) TSHR
SCHEMBL476933 0.76 TSHR (0.39) TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3004050-B1 CYANOSTILBENES ROLIC TECH AG (CH) 2020-09-02 EP disclosed
CN-111533668-A Cyanostilbenes 罗利克技术有限公司 2020-08-14 CN disclosed
US-10329486-B2 Cyanostilbenes ROLIC AG (CH) 2019-06-25 US disclosed
CN-105567260-B Functionalized photoreactive compounds 罗利克有限公司 2018-09-11 CN disclosed
CN-105567260-A Print Functionalized photoreactive compounds ROLIC AG 2016-05-11 CN disclosed
EP-3004050-A1 CYANOSTILBENES Rolic AG (CH) 2016-04-13 EP disclosed
US-20160083655-A1 CYANOSTILBENES ROLIC AG (CH) 2016-03-24 US disclosed
CN-101268168-B Functionalized photoreactive compounds ROLIC AG (CH) 2016-01-20 CN disclosed
US-9217920-B2 Photocurable compositions 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-12-22 US disclosed
US-20150248055-A1 PHOTOCURABLE COMPOSITIONS 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-09-03 US disclosed
US-7897678-B2 Fluorochemical urethane compounds having pendent silyl groups 3M INNOVATIVE PROPERTIES COMPANY (US) 2011-03-01 US disclosed
CN-101754991-A fluorochemical urethane compounds having pendent silyl groups 3M INNOVATIVE PROPERTIES CO 2010-06-23 CN disclosed
EP-2178940-A1 FLUOROCHEMICAL URETHANE COMPOUNDS HAVING PENDENT SILYL GROUPS 3M Innovative Properties Company (US) 2010-04-28 EP disclosed
US-20090294362-A1 STATIONARY PHASE FOR HYDROPHILIC INTERACTION CHROMATOGRAPHY MERCK PATENT GMBH (DE) 2009-12-03 US disclosed
EP-1928979-B1 FUNCTIONALIZED PHOTOREACTIVE COMPOUNDS ROLIC AG (CH) 2009-03-04 EP disclosed
US-20090025608-A1 FLUOROCHEMICAL URETHANE COMPOUNDS HAVING PENDENT SILYL GROUPS 3M INNOVATIVE PROPERTIES COMPANY 2009-01-29 US disclosed
WO-2009015258-A1 FLUOROCHEMICAL URETHANE COMPOUNDS HAVING PENDENT SILYL GROUPS 3M INNOVATIVE PROPERTIES COMPANY (US) 2009-01-29 WO disclosed
US-20080274304-A1 Functionalized Photoreactive Compounds ROLIC AG (CH) 2008-11-06 US disclosed
CN-101268168-A Functionalized photoreactive compounds ROLIC AG (CH) 2008-09-17 CN disclosed
EP-1764405-A1 Functionalized photoreactive compounds Rolic AG (CH) 2007-03-21 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080274304-A1 Functionalized Photoreactive Compounds PCNA, PIN1, MAP1LC3C TSHR 4847/4885SLC1A2 1020/4885CHRM2 3643/4885
US-20160083655-A1 CYANOSTILBENES LATS1, LATS2, CRY1 TSHR 4718/4885SLC1A2 1261/4885CHRM2 1897/4885
US-10329486-B2 Cyanostilbenes LATS1, LATS2, CRY1 TSHR 4718/4885SLC1A2 1261/4885CHRM2 1897/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.