Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGIR | P43119 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.37 |
| ▸ | HTR7 | P34969 | 2/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.37 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NISCH | Q9Y2I1 | 4/20 | 0.36 |
| ▸ | MAOA | P21397 | 4/20 | 0.36 |
| ▸ | MAOB | P27338 | 4/20 | 0.36 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.35 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042630 | 0.88 | CYP2D6 (0.46) | PTGIRADRA2AHTR7ADRA1AADRA2B | |
| SCHEMBL4788240 | 0.86 | ADRA2A (0.44) | PTGIRADRA2AHTR7ADRA1AADRA2B | |
| SCHEMBL3430372 | 0.82 | WDR5 (0.42) | PTGIRHTR7SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL14042623 | 0.79 | PTGIR (0.47) | PTGIRMAPTADRA2AADRA2BADRA2C | |
| SCHEMBL14042628 | 0.76 | NISCH (0.50) | LMNAMAPTADRA2AADRA1AADRA2B | |
| SCHEMBL14042629 | 0.76 | NISCH (0.46) | PTGIRLMNAADRA2AHTR7ADRA1A | |
| SCHEMBL14042574 | 0.76 | LMNA (0.46) | PTGIRLMNAADRA2AHTR7ADRA1A | |
| SCHEMBL14042632 | 0.75 | LMNA (0.44) | PTGIRLMNAADRA2AHTR7ADRA1A | |
| SCHEMBL949042 | 0.73 | KDM4E (0.52) | PTGIRLMNAADRA2AADRA1AADRA2B | |
| SCHEMBL4788507 | 0.73 | SLC6A2 (0.46) | LMNAADRA2AADRA1AADRA2BADRA2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008123821-A1 | 4, 5-DIHYDRO-LH-IMIDAZOL-2-AMINE DERIVATIVES FOR USE IN THE TREATMENT OF RESPIRATORY, CARDIOVASCULAR, NEUROLOGICAL OR GASTROINTESTINAL DISORDERS | ALBIREO AB (SE) | 2008-10-16 | — | — | WO | disclosed |