Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.38 |
| ▸ | DCTPP1 | Q9H773 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 3/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.33 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11943857 | 0.94 | ALDH1A1 (0.44) | ALDH1A1NPBWR1MCHR1SMN1; SMN2DCTPP1 | |
| SCHEMBL14080985 | 0.83 | NPBWR1 (0.37) | ALDH1A1NPBWR1MCHR1SMN1; SMN2DCTPP1 | |
| SCHEMBL11943855 | 0.82 | ALDH1A1 (0.41) | ALDH1A1NPBWR1MCHR1SMN1; SMN2DCTPP1 | |
| SCHEMBL17058437 | 0.82 | ALDH1A1 (0.40) | ALDH1A1NPBWR1MCHR1SMN1; SMN2DCTPP1 | |
| SCHEMBL11943861 | 0.81 | ALDH1A1 (0.37) | ALDH1A1NPBWR1MCHR1SMN1; SMN2DCTPP1 | |
| SCHEMBL17057920 | 0.81 | MCHR1 (0.37) | ALDH1A1NPBWR1MCHR1SMN1; SMN2KDM4E | |
| SCHEMBL17058160 | 0.79 | MAPT (0.46) | ALDH1A1SMN1; SMN2KDM4EPKMLMNA | |
| SCHEMBL11943856 | 0.79 | ROCK2 (0.42) | ALDH1A1NPBWR1MCHR1SMN1; SMN2DCTPP1 | |
| SCHEMBL17057930 | 0.78 | POLB (0.45) | ALDH1A1NPBWR1MCHR1SMN1; SMN2KDM4E | |
| SCHEMBL14899749 | 0.78 | SMN1; SMN2 (0.45) | ALDH1A1NPBWR1MCHR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008115381-A1 | PYRIDAZINONE DERIVATIVES USEFUL AS GLUCAN SYNTHASE INHIBITORS | SCHERING CORPORATION (US) | 2008-09-25 | — | — | WO | disclosed |