Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromethamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMO | O15229 | 5/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.31 |
| ▸ | RXRA | P19793 | 4/20 | 0.31 |
| ▸ | RXRB | P28702 | 4/20 | 0.31 |
| ▸ | RXRG | P48443 | 4/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.31 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1410139 | 0.92 | LMNA (0.41) | LMNAFFAR4FFAR1SLC6A2SLC6A4 | |
| SCHEMBL1410779 | 0.92 | LMNA (0.41) | LMNAFFAR4FFAR1SLC6A2SLC6A4 | |
| SCHEMBL1410337 | 0.92 | LMNA (0.41) | LMNAFFAR4FFAR1SLC6A2SLC6A4 | |
| SCHEMBL1410366 | 0.84 | FFAR1 (0.47) | LMNAFFAR4FFAR1SLC6A2SLC6A4 | |
| SCHEMBL1410504 | 0.81 | RXRA (0.42) | FFAR4FFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1410689 | 0.80 | FFAR4 (0.44) | LMNAFFAR4FFAR1SLC6A2SLC6A4 | |
| SCHEMBL1409539 | 0.80 | FFAR1 (0.47) | FFAR4FFAR1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL1410134 | 0.77 | ALDH1A1 (0.38) | SLC6A2SLC6A4SLC6A3RORC | |
| SCHEMBL1410421 | 0.75 | PTGIR (0.38) | LMNAFFAR4FFAR1TACR1RXRA | |
| SCHEMBL1410431 | 0.73 | FFAR4 (0.40) | FFAR4FFAR1SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295406-B1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL (JP) | 2014-04-23 | — | — | EP | disclosed |
| US-8338622-B2 | Heterocyclic compound | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-12-25 | — | — | US | disclosed |
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-10-13 | — | — | US | disclosed |
| EP-2295406-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2011-03-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110251187-A1 | HETEROCYCLIC COMPOUND | NES, BMI1, DOT1L | LMNA 2590/4885KMO 3319/4885FFAR4 4589/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.