Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 19/20 | 0.54 |
| ▸ | HTR2B | P41595 | 8/20 | 0.54 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | HTR7 | P34969 | 3/20 | 0.54 |
| ▸ | DRD2 | P14416 | 5/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14107045 | 0.79 | HTR6 (0.50) | HTR6HTR1AHTR7DRD2HTR2A | |
| SCHEMBL14106930 | 0.72 | DYRK1A (0.37) | HTR6MAPT | |
| SCHEMBL29437710 | 0.70 | HTR6 (1.00) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL14106926 | 0.69 | ALDH1A1 (0.37) | HTR6MAPT | |
| SCHEMBL14106929 | 0.68 | GHSR (0.38) | HTR6DRD3 | |
| SCHEMBL5091047 | 0.67 | HTR6 (0.63) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL3625209 | 0.66 | HTR6 (0.48) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL3078215 | 0.65 | HTR6 (0.69) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL5097162 | 0.65 | HTR6 (0.61) | HTR6HTR2BHTR1AHTR7DRD2 | |
| SCHEMBL8427699 | 0.65 | HTR6 (0.68) | HTR6HTR2BHTR1AHTR7DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008101247-A2 | 6 ' SUBSTITUTED INDOLE AND INDAZOLE DERIVATIVES HAVING 5-HT6 RECEPTOR AFFINITY | MEMORY PHARMACEUTICALS CORPORATION (US) | 2008-08-21 | — | — | WO | disclosed |