Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | COPS5 | Q92905 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5037086 | 0.82 | SMN1; SMN2 (0.57) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL14109006 | 0.82 | RAB9A (0.48) | HTTALDH1A1SMN1; SMN2GRM4RAB9A | |
| SCHEMBL4285070 | 0.82 | GPR52 (0.50) | KMT2AALDH1A1SMN1; SMN2LMNARAB9A | |
| SCHEMBL14109365 | 0.80 | GPR52 (0.55) | HTTKMT2AGRM4LMNARAB9A | |
| SCHEMBL14108778 | 0.78 | TP53 (0.44) | HTTKMT2ASMN1; SMN2GRM4LMNA | |
| SCHEMBL14109406 | 0.76 | MAPT (0.57) | HTTKMT2AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL14108966 | 0.74 | GPR52 (0.54) | SMN1; SMN2LMNATP53RAB9AMAPT | |
| SCHEMBL14108608 | 0.73 | CACNA1G (0.43) | KMT2AGRM4RAB9AMEN1GAA | |
| SCHEMBL18321159 | 0.73 | PTGDR2 (0.49) | KMT2AALDH1A1SMN1; SMN2LMNATP53 | |
| SCHEMBL14109268 | 0.72 | GLS (0.44) | KMT2AALDH1A1SMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2530078-A1 | THIAZOLE DERIVATIVE | Takeda Pharmaceutical Company Limited (JP) | 2012-12-05 | — | — | EP | disclosed |