Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRL1 | P41146 | 2/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | PLD2 | O14939 | 1/20 | 0.46 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | DRD1 | P21728 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.44 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.44 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.44 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13864847 | 0.84 | OPRL1 (0.48) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL1138302 | 0.79 | SLC6A9 (0.58) | OPRL1OPRM1OPRD1OPRK1 | |
| SCHEMBL4462811 | 0.78 | OPRM1 (0.46) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL6006756 | 0.78 | OPRD1 (0.39) | OPRL1OPRM1OPRD1SIGMAR1PLD2 | |
| SCHEMBL4558250 | 0.77 | CRBN (0.46) | SIGMAR1PLD2PLD1TSHRLMNA | |
| SCHEMBL17113644 | 0.76 | OPRM1 (0.50) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL18075896 | 0.75 | SIGMAR1 (0.48) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL2604320 | 0.75 | TSHR (0.75) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL17101341 | 0.72 | SIGMAR1 (0.45) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 | |
| SCHEMBL17101331 | 0.71 | TSHR (0.68) | OPRL1OPRM1OPRD1OPRK1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1390372-B1 | 1-OXA-3,9-DIAZA-SPIRO'5,5]UNDECAN-2-ONES DERIVATIVES AND ITS USE AS ANTAGONIST OF THE NEURIKININ RECEPTOR | HOFFMANN LA ROCHE (CH) | 2008-07-16 | — | — | EP | disclosed |