Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | PLD2 | O14939 | 1/20 | 0.38 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.38 |
| ▸ | SLC6A9 | P48067 | 12/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 6/20 | 0.36 |
| ▸ | SLC6A5 | Q9Y345 | 3/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16182201 | 0.79 | OPRD1 (0.40) | OPRD1HSD17B10SIGMAR1OPRM1KCNH2 | |
| SCHEMBL4558250 | 0.77 | CRBN (0.46) | PLD2PLD1SIGMAR1 | |
| SCHEMBL11364638 | 0.76 | OPRD1 (0.40) | OPRD1HSD17B10SIGMAR1OPRM1KCNH2 | |
| SCHEMBL1138335 | 0.74 | SLC6A9 (0.56) | SLC6A9OPRM1SLC6A5OPRL1KCNH2 | |
| SCHEMBL5012152 | 0.70 | CYP3A4 (0.53) | OPRD1HSD17B10 | |
| SCHEMBL5010920 | 0.70 | CYP3A4 (0.53) | OPRD1HSD17B10 | |
| SCHEMBL16336083 | 0.70 | TAAR1 (0.34) | OPRD1HSD17B10SLC6A9SIGMAR1SLC18A3 | |
| SCHEMBL13277562 | 0.68 | HTR2A (0.37) | OPRD1SLC6A9SIGMAR1OPRM1KCNH2 | |
| SCHEMBL17135722 | 0.67 | OPRM1 (0.44) | OPRD1HSD17B10SIGMAR1OPRM1SLC18A3 | |
| SCHEMBL17968386 | 0.67 | SIGMAR1 (0.44) | OPRD1HSD17B10SIGMAR1OPRM1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716156-A2 | CHEMOKINE CCR5 RECEPTOR MODULATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2006-11-02 | — | — | EP | disclosed |
| WO-2005075484-A2 | CHEMOKINE CCR5 RECEPTOR MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2005-08-18 | — | — | WO | disclosed |