Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 1/20 | 0.71 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.58 |
| ▸ | RAB9A | P51151 | 1/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | MAOB | P27338 | 1/20 | 0.54 |
| ▸ | NQO1 | P15559 | 2/20 | 0.51 |
| ▸ | CA12 | O43570 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | CDC25A | P30304 | 2/20 | 0.48 |
| ▸ | CDC25C | P30307 | 2/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.44 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1414225 | 1.00 | ALDH1A1 (0.71) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL25361394 | 0.84 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL21457082 | 0.82 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL21457085 | 0.82 | ALDH1A1 (0.54) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL28695610 | 0.81 | NQO1 (0.53) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL17384233 | 0.81 | ALDH1A1 (0.49) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL17384225 | 0.80 | CDC25A (0.69) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL1395382 | 0.79 | NQO1 (0.58) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL15953090 | 0.77 | NQO1 (0.61) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E | |
| SCHEMBL3210892 | 0.77 | NQO1 (0.56) | ALDH1A1SMN1; SMN2LMNAHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295053-B1 | Novel 2H-chromen-2-one-3-carboxamides for medical uses | INST MATERIA MEDICA CAMS (CN) | 2016-10-19 | — | — | EP | disclosed |
| US-8338401-B2 | Coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2012-12-25 | — | — | US | disclosed |
| EP-2295053-A1 | Novel 2H-chromen-2-one-3-carboxamides for medical uses | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2011-03-16 | — | — | EP | disclosed |
| US-20060148834-A1 | Novel coumarin-amide derivatives and its preparation, said drug composition and its use | INSTITUTE OF MATERIA MEDICA CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2006-07-06 | — | — | US | disclosed |
| EP-1570846-A1 | THE NOVEL COUMARIN-AMIDE DERIVATIVES AND ITS PREPARATION, SAID DRUG COMPOSITION AND ITS USE | THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES (CN) | 2005-09-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060148834-A1 | Novel coumarin-amide derivatives and its preparation, said drug composition and its use | INSR, GLS, INSRR | ALDH1A1 1795/4885SMN1; SMN2 4803/4885LMNA 21/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.