Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | PPARG | P37231 | 2/20 | 0.33 |
| ▸ | PPARA | Q07869 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | GPX4 | P36969 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.32 |
| ▸ | CTSG | P08311 | 1/20 | 0.32 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.32 |
| ▸ | CMA1 | P23946 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200442 | 0.92 | MAPK1 (0.37) | PPARGPPARACNR2NPC1ALDH1A1 | |
| SCHEMBL14200468 | 0.92 | MTNR1B (0.34) | RENMTNR1BPRKCAPRKCDPDK1 | |
| SCHEMBL14229204 | 0.87 | TP53 (0.37) | CNR2NPC1ALDH1A1TP53GPX4 | |
| SCHEMBL14200451 | 0.87 | PRKCA (0.36) | RENPPARGPPARACNR2NPC1 | |
| SCHEMBL14200453 | 0.87 | MTNR1B (0.35) | RENALDH1A1TP53MTNR1BPDK1 | |
| SCHEMBL14200481 | 0.86 | ALDH1A1 (0.46) | NPC1ALDH1A1TP53GPX4RAB9A | |
| SCHEMBL14200990 | 0.85 | RIPK1 (0.37) | NPC1ALDH1A1TP53GPX4RAB9A | |
| SCHEMBL14200432 | 0.85 | EPHX2 (0.41) | NPC1ALDH1A1 | |
| SCHEMBL14200454 | 0.84 | MTNR1B (0.35) | RENMTNR1BPRKCAPRKCDPDK1 | |
| SCHEMBL14229351 | 0.84 | MTNR1B (0.37) | RENCNR2NPC1ALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |