Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 1/20 | 0.34 |
| ▸ | REN | P00797 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.33 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.33 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.33 |
| ▸ | PRKCA | P17252 | 1/20 | 0.33 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 6/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.31 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.31 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.31 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.31 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.31 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.31 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.31 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200470 | 0.92 | REN (0.36) | MTNR1BRENPDK1PDK2PDK3 | |
| SCHEMBL14200447 | 0.91 | MAPK1 (0.36) | TAS1R3TAS1R1HDAC1HDAC6 | |
| SCHEMBL14200453 | 0.90 | MTNR1B (0.35) | MTNR1BRENPDK1PDK2PDK3 | |
| SCHEMBL14200454 | 0.90 | MTNR1B (0.35) | MTNR1BRENPDK1PDK2PDK3 | |
| SCHEMBL14229373 | 0.86 | TP53 (0.39) | MTNR1BTAS1R3TAS1R1PRKCAPRKCD | |
| SCHEMBL14200451 | 0.85 | PRKCA (0.36) | MTNR1BRENPDK1PDK2PDK3 | |
| SCHEMBL14200458 | 0.85 | TAS1R3 (0.42) | TAS1R3TAS1R1PSEN1PSEN2APH1B | |
| SCHEMBL14200460 | 0.85 | MTNR1B (0.36) | MTNR1BPDK1PDK2PDK3PDK4 | |
| SCHEMBL14200978 | 0.84 | RIPK1 (0.39) | MTNR1BPOLBRIPK1 | |
| SCHEMBL14200443 | 0.84 | ALDH1A1 (0.41) | TAS1R3TAS1R1PSEN1PSEN2APH1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |