Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.44 |
| ▸ | STAT3 | P40763 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200767 | 0.91 | LDHA (0.42) | LDHASTAT3L3MBTL1ALDH1A1ACHE | |
| SCHEMBL14200770 | 0.89 | EPHX2 (0.44) | — | |
| SCHEMBL14229054 | 0.85 | LDHA (0.46) | LDHASTAT3L3MBTL1ALDH1A1ACHE | |
| SCHEMBL14200831 | 0.84 | LDHA (0.43) | LDHASTAT3L3MBTL1ALDH1A1ACHE | |
| SCHEMBL14200763 | 0.82 | SIGMAR1 (0.42) | LDHASTAT3ALDH1A1 | |
| SCHEMBL14200827 | 0.82 | TRPM8 (0.37) | L3MBTL1ALDH1A1ACHEMEN1KMT2A | |
| SCHEMBL14200838 | 0.82 | ALDH1A1 (0.45) | L3MBTL1ALDH1A1ACHEMEN1KMT2A | |
| SCHEMBL14200909 | 0.80 | RIPK1 (0.49) | ALDH1A1 | |
| SCHEMBL14200876 | 0.80 | F2R (0.45) | — | |
| SCHEMBL9781324 | 0.80 | LDHA (0.46) | LDHASTAT3L3MBTL1ALDH1A1ACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |