Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.39 |
| ▸ | GSTO1 | P78417 | 1/20 | 0.39 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.39 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14200770 | 0.93 | EPHX2 (0.44) | — | |
| SCHEMBL14200830 | 0.91 | LDHA (0.44) | LDHAMEN1KMT2ASTAT3L3MBTL1 | |
| SCHEMBL14200831 | 0.89 | LDHA (0.43) | LDHAMEN1KMT2ASTAT3MAPT | |
| SCHEMBL14229512 | 0.87 | LDHA (0.45) | LDHAMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL14230039 | 0.86 | LDHA (0.47) | LDHAMEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL14200763 | 0.85 | SIGMAR1 (0.42) | LDHASTAT3ALDH1A1 | |
| SCHEMBL14200765 | 0.83 | TAS1R3 (0.36) | MEN1KMT2AL3MBTL1ALDH1A1NPC1 | |
| SCHEMBL14200860 | 0.83 | TSPO (0.42) | MEN1KMT2AMAPTL3MBTL1ALDH1A1 | |
| SCHEMBL14200878 | 0.81 | RIPK1 (0.47) | ALDH1A1HTTRAB9A | |
| SCHEMBL14200843 | 0.81 | PSEN1 (0.41) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365093-B2 | Endothelin antagonists | ABBOTT LABORATORIES (US) | 2008-04-29 | — | — | US | disclosed |
| US-7208517-B1 | Endothelin antagonists | ABBOTT LABORTORIES (US) | 2007-04-24 | — | — | US | disclosed |