Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 8/20 | 0.51 |
| ▸ | ORAI1 | Q96D31 | 8/20 | 0.51 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | LDHA | P00338 | 2/20 | 0.48 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.46 |
| ▸ | UCHL3 | P15374 | 1/20 | 0.46 |
| ▸ | UCHL5 | Q9Y5K5 | 1/20 | 0.46 |
| ▸ | KMO | O15229 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CA4 | P22748 | 1/20 | 0.45 |
| ▸ | CA7 | P43166 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | TRPC1 | P48995 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22530587 | 0.84 | P2RY14 (0.49) | RXRARXRBNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15835844 | 0.79 | CHRNB2 (0.47) | KMOCA9 | |
| SCHEMBL14233963 | 0.77 | UCHL5 (0.58) | STIM1ORAI1KEAP1NFE2L2LDHA | |
| SCHEMBL26156421 | 0.77 | CYP19A1 (0.45) | NPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL14212103 | 0.74 | GPR55 (0.39) | STIM1ORAI1KEAP1NFE2L2NPC1 | |
| SCHEMBL26803794 | 0.74 | STIM1 (0.69) | STIM1ORAI1KEAP1NFE2L2LDHA | |
| SCHEMBL29946192 | 0.73 | STIM1 (0.76) | STIM1ORAI1KEAP1NFE2L2LDHA | |
| SCHEMBL26628304 | 0.73 | STIM1 (0.76) | STIM1ORAI1KEAP1NFE2L2LDHA | |
| SCHEMBL21470628 | 0.73 | MIF (0.51) | SMN1; SMN2HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL22530445 | 0.72 | P2RY14 (0.45) | RXRARXRBNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120309794-A1 | COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | UNIVERSITÀ DI PISA (IT) | 2012-12-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120309794-A1 | COMPOUNDS INHIBITORS OF ENZYME LACTATE DEHYDROGENASE (LDH) AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | LDHA, LDHB, DLD | STIM1 2377/4885ORAI1 2350/4885KEAP1 765/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.