Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.39 |
| ▸ | PARG | Q86W56 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14218083 | 0.86 | PARG (0.36) | PRMT1PARGKCNH2MCHR1CNR2 | |
| SCHEMBL14218080 | 0.78 | EGFR (0.42) | CNR2ALDH1A1HTR6EGFRIGF1R | |
| SCHEMBL14218048 | 0.77 | S1PR3 (0.38) | LMNACNR2ALDH1A1PLA2G2A | |
| SCHEMBL14218081 | 0.76 | PARG (0.38) | PRMT1PARGKCNH2MCHR1CNR2 | |
| SCHEMBL14217998 | 0.75 | ALDH1A1 (0.41) | PARGKCNH2MCHR1GABRA1GABRA5 | |
| SCHEMBL12579072 | 0.73 | HTR6 (0.45) | PARGKCNH2MCHR1PKMLMNA | |
| SCHEMBL2024849 | 0.73 | HTR6 (0.45) | PARGKCNH2MCHR1PKMLMNA | |
| SCHEMBL2022246 | 0.73 | HTR6 (0.45) | PARGKCNH2MCHR1PKMLMNA | |
| SCHEMBL14624587 | 0.73 | PTGDR2 (0.42) | CNR2EGFRIGF1RFLT4KDR | |
| SCHEMBL14218082 | 0.72 | PARG (0.34) | PARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063867-A2 | TETRAHYDROCYCLOPENTA[B] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |