Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.35 |
| ▸ | PLA2G2A | P14555 | 2/20 | 0.35 |
| ▸ | PARG | Q86W56 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 4/20 | 0.34 |
| ▸ | HTR6 | P50406 | 4/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | FLT4 | P35916 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2024874 | 0.87 | HRH1 (0.48) | ALDH1A1MEN1PKMKMT2ACNR2 | |
| SCHEMBL14218080 | 0.81 | EGFR (0.42) | ALDH1A1MEN1KMT2ACNR2HSD17B10 | |
| SCHEMBL14217954 | 0.75 | PRMT1 (0.39) | ALDH1A1PKMCNR2GABRA1GABRA5 | |
| SCHEMBL13478801 | 0.75 | HTR6 (0.55) | CNR2HRH1HTR6 | |
| SCHEMBL14217957 | 0.75 | HTR6 (0.52) | CNR2HRH1HTR6 | |
| SCHEMBL14218083 | 0.75 | PARG (0.36) | CNR2PLA2G2APARGKCNH2MCHR1 | |
| SCHEMBL14218081 | 0.74 | PARG (0.38) | ALDH1A1CNR2PLA2G2APARGKCNH2 | |
| SCHEMBL12579010 | 0.73 | HRH1 (0.37) | PARGHRH1HTR6BCHEACHE | |
| SCHEMBL2023120 | 0.73 | HRH1 (0.37) | PARGHRH1HTR6BCHEACHE | |
| SCHEMBL14218050 | 0.73 | PLA2G2A (0.41) | ALDH1A1CNR2PLA2G2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008063867-A2 | TETRAHYDROCYCLOPENTA[B] INDOLE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2008-05-29 | — | — | WO | disclosed |