Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.45 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.45 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.45 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.43 |
| ▸ | POLA1 | P09884 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL104931 | 0.82 | PDE4A (0.64) | ADORA3ALDH1A1CYP2D6PDPK1GDA | |
| SCHEMBL29557469 | 0.82 | PDE4A (0.64) | ADORA3ALDH1A1CYP2D6PDPK1GDA | |
| SCHEMBL1980128 | 0.82 | PDPK1 (0.45) | ADORA3CYP2D6PDPK1GDAPDE4A | |
| SCHEMBL13268695 | 0.81 | ENPP1 (0.46) | ADORA3ALDH1A1PDPK1GDAPOLA1 | |
| SCHEMBL1422153 | 0.79 | ALDH1A1 (0.47) | MAPTALDH1A1CYP2D6ATMADORA1 | |
| SCHEMBL10276353 | 0.77 | TSHR (0.42) | ALDH1A1PDPK1GDAPDE4APDE4B | |
| Adenine SCHEMBL7891002 | 0.75 | PI4KA (0.56) | ALDH1A1CYP2D6PDPK1GDAPDE4A | |
| Phosphoric Acid SCHEMBL27565804 | 0.75 | PDE4A (0.56) | ADORA3ALDH1A1CYP2D6PDPK1GDA | |
| SCHEMBL14696427 | 0.74 | TYR (0.46) | — | |
| SCHEMBL16486348 | 0.74 | ALDH1A1 (0.57) | MAPTADORA3ALDH1A1CYP2D6ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENRIFIQUE (CNRS) | 2011-06-30 | — | — | US | disclosed |
| EP-2297075-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009147217-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | TUBB4A, TUBA4A, TUBGCP4 | MAPT 132/4885ADORA3 3445/4885ALDH1A1 2212/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.