Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MPO | P05164 | 1/20 | 0.41 |
| ▸ | QTRT1 | Q9BXR0 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | DHFR | P00374 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28320162 | 0.82 | HTR6 (0.38) | ALDH1A1CYP2D6LMNASMN1; SMN2HTR6 | |
| SCHEMBL217337 | 0.82 | ADORA1 (0.47) | CYP2D6ADORA1 | |
| SCHEMBL30958478 | 0.82 | APLNR (0.42) | HTR6HTTMAPTDHFRADORA1 | |
| SCHEMBL15300300 | 0.82 | MPO (0.41) | ALDH1A1LMNASMN1; SMN2HTTHSD17B10 | |
| SCHEMBL13268694 | 0.81 | CALM1 (0.43) | ALDH1A1LMNAHTTDHFR | |
| SCHEMBL1422155 | 0.79 | MAPT (0.51) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL6941905 | 0.79 | ALDH1A1 (0.50) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL16486348 | 0.76 | ALDH1A1 (0.57) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL4237792 | 0.76 | MAPT (0.41) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 | |
| SCHEMBL27954147 | 0.74 | ALDH1A1 (0.47) | ALDH1A1CYP2D6ATMLMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENRIFIQUE (CNRS) | 2011-06-30 | — | — | US | disclosed |
| EP-2297075-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-03-23 | — | — | EP | disclosed |
| WO-2009147217-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2009-12-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110160228-A1 | DIHYDRO-ISO-CA-4 AND ANALOGUES: POTENT CYTOTOXICS, INHIBITORS OF TUBULIN POLYMERIZATION | TUBB4A, TUBA4A, TUBGCP4 | ALDH1A1 2212/4885CYP2D6 1337/4885ATM 3940/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.