Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.36 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.32 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | EGFR | P00533 | 2/20 | 0.32 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | UGCG | Q16739 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237503 | 0.90 | KCNH2 (0.36) | KCNH2RPA1SIGMAR1NPBWR1MCHR1 | |
| SCHEMBL14237484 | 0.88 | KCNH2 (0.35) | KCNH2RPA1SIGMAR1NPBWR1MCHR1 | |
| SCHEMBL14237570 | 0.87 | SMN1; SMN2 (0.37) | KCNH2RIPK2KMT2AUGCG | |
| SCHEMBL14237370 | 0.86 | NPC1 (0.40) | KCNH2RPA1KMT2AERBB2NOTUM | |
| SCHEMBL14237683 | 0.85 | CNR1 (0.37) | KMT2A | |
| SCHEMBL2546838 | 0.85 | KCNH2 (0.39) | KCNH2SIGMAR1NPBWR1MCHR1EGFR | |
| SCHEMBL14237366 | 0.84 | GPR119 (0.36) | — | |
| SCHEMBL2542448 | 0.80 | NPBWR1 (0.51) | NPBWR1MCHR1 | |
| SCHEMBL4718944 | 0.75 | HRH1 (0.47) | KCNH2HRH1CCR3 | |
| SCHEMBL2540908 | 0.73 | KCNH2 (0.39) | KCNH2RPA1SIGMAR1EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |