Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.35 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
| ▸ | RPA1 | P27694 | 3/20 | 0.33 |
| ▸ | UGCG | Q16739 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 5/20 | 0.32 |
| ▸ | CNR2 | P34972 | 5/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14237503 | 0.91 | KCNH2 (0.36) | KCNH2RPA1UGCGNOTUMCNR1 | |
| SCHEMBL14237570 | 0.90 | SMN1; SMN2 (0.37) | KCNH2RIPK2UGCGCNR1CNR2 | |
| SCHEMBL14237704 | 0.88 | KCNH2 (0.36) | KCNH2RIPK2RPA1UGCGNOTUM | |
| SCHEMBL14237370 | 0.87 | NPC1 (0.40) | KCNH2RPA1UGCGNOTUMCNR1 | |
| SCHEMBL14237683 | 0.87 | CNR1 (0.37) | CNR1CNR2 | |
| SCHEMBL2544216 | 0.84 | KCNH2 (0.38) | KCNH2RPA1NOTUM | |
| SCHEMBL2542457 | 0.80 | NPBWR1 (0.51) | NPBWR1MCHR1 | |
| SCHEMBL4718944 | 0.76 | HRH1 (0.47) | KCNH2 | |
| SCHEMBL2540908 | 0.75 | KCNH2 (0.39) | KCNH2RPA1NOTUMSIGMAR1 | |
| SCHEMBL14237689 | 0.74 | GPR119 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | claimed |
| EP-2313395-B1 | PYRIDONE AND PYRIDAZONE ANALOGUES AS GPR119 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2012-12-19 | — | — | EP | disclosed |