Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.31 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4291668 | 0.99 | PTGS1 (0.43) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL1425324 | 0.86 | MAPT (0.44) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL9616973 | 0.78 | LOX (0.39) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL13415787 | 0.69 | LMNA (0.45) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL14446344 | 0.68 | LOX (0.43) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL9616703 | 0.66 | LOX (0.41) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL30834844 | 0.64 | POLB (0.35) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL19829483 | 0.64 | LOX (0.39) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL2784650 | 0.64 | LMNA (0.40) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| Metamizole SCHEMBL867884 | 0.61 | PTGS1 (0.97) | PTGS1LMNAMAPTKDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9579299-B2 | CNS pharmaceutical compositions and methods of use | TARGIA PHARMACEUTICALS (IL) | 2017-02-28 | — | — | US | disclosed |
| WO-2016027259-A1 | CNS PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | TARGIA PHARMACEUTICALS (IL) | 2016-02-25 | — | — | WO | disclosed |
| US-20140256709-A1 | CNS PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | TARGIA PHARMACEUTICALS (IL) | 2014-09-11 | — | — | US | disclosed |
| US-8729070-B2 | CNS pharmaceutical compositions and methods of use | TARGIA PHARMACEUTICALS (IL) | 2014-05-20 | — | — | US | disclosed |
| EP-2012763-B1 | PHARMACEUTICAL COMBINATION COMPRISING 3- (3-DIMETHYLAMIN0-1-ETHYL-2-METHYL-PR0PYL) -PHENOL AND AN NSAID | GRUENENTHAL GMBH (DE) | 2011-03-23 | — | — | EP | disclosed |
| US-20110054038-A1 | CNS PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | TARGIA PHARMACEUTICALS (IL) | 2011-03-03 | — | — | US | disclosed |
| EP-2254420-A2 | CNS PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | Targia Pharmaceuticals (IL) | 2010-12-01 | — | — | EP | disclosed |
| WO-2009104080-A2 | CNS PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE | TARGIA PHARMACEUTICALS (IL) | 2009-08-27 | — | — | WO | disclosed |