Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | LOX | P28300 | 1/20 | 0.32 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.32 |
| ▸ | LOXL4 | Q96JB6 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1425325 | 0.99 | PTGS1 (0.42) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL1425324 | 0.87 | MAPT (0.44) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL9616973 | 0.79 | LOX (0.39) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL13415787 | 0.70 | LMNA (0.45) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL14446344 | 0.69 | LOX (0.43) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL9616703 | 0.67 | LOX (0.41) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL30834844 | 0.65 | POLB (0.35) | PTGS1LMNAABCB11MAPTKDM4E | |
| SCHEMBL19829483 | 0.64 | LOX (0.39) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL2784650 | 0.64 | LMNA (0.40) | PTGS1LMNAABCB11MAPTALDH1A1 | |
| SCHEMBL8217266 | 0.61 | LOX (0.36) | PTGS1LMNAABCB11MAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160361276-A1 | Pharmaceutical Combination | GRUENENTHAL GMBH (DE) | 2016-12-15 | — | — | US | disclosed |
| US-20160045459-A1 | Pharmaceutical Combination | GRUENENTHAL GMBH (DE) | 2016-02-18 | — | — | US | disclosed |
| US-20130190333-A1 | Pharmaceutical Combination | GRUENENTHAL GMBH (DE) | 2013-07-25 | — | — | US | disclosed |
| US-20090099138-A1 | NSAIDs and tapentadol; synergistic pain relief | GRUENENTHAL GMBH (DE) | 2009-04-16 | — | — | US | disclosed |
| EP-2012763-A1 | PHARMACEUTICAL COMBINATION COMPRISING 3- (3-DIMETHYLAMIN0-1-ETHYL-2-METHYL-PR0PYL) -PHENOL AND AN NSAID | Grünenthal GmbH (DE) | 2009-01-14 | — | — | EP | disclosed |
| WO-2007128412-A1 | PHARMACEUTICAL COMBINATION COMPRISING 3- (3-DIMETHYLAMIN0-1-ETHYL-2-METHYL-PR0PYL) -PHENOL AND AN NSAID | Grünenthal GmbH (DE) | 2007-11-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160361276-A1 | Pharmaceutical Combination | MC2R, PTGER2, PTGER1 | PTGS1 4/4885LMNA 2623/4885ABCB11 464/4885 |
| US-20160045459-A1 | Pharmaceutical Combination | MC2R, PTGER2, PTGER1 | PTGS1 4/4885LMNA 2623/4885ABCB11 464/4885 |
| US-20130190333-A1 | Pharmaceutical Combination | MC2R, PTGER2, PTGER1 | PTGS1 4/4885LMNA 2623/4885ABCB11 464/4885 |
| US-20090099138-A1 | NSAIDs and tapentadol; synergistic pain relief | PTGS1, OPRL1, PTGES3 | PTGS1 1/4885LMNA 3462/4885ABCB11 652/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.