Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | RORC | P51449 | 5/20 | 0.47 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.46 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.46 |
| ▸ | MLYCD | O95822 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RORA | P35398 | 3/20 | 0.43 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | RORB | Q92753 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255603 | 0.78 | NR1H2 (0.49) | SMN1; SMN2RORCNR1H3NR1H2MLYCD | |
| SCHEMBL4873262 | 0.77 | SMN1; SMN2 (0.54) | NPSR1SMN1; SMN2RORCNR1H3NR1H2 | |
| SCHEMBL4883281 | 0.75 | LMNA (0.52) | SMN1; SMN2RORCNR1H3NR1H2MLYCD | |
| SCHEMBL4422384 | 0.74 | NR1H2 (0.44) | SMN1; SMN2RORCNR1H3NR1H2MLYCD | |
| SCHEMBL10192180 | 0.73 | NPSR1 (0.69) | NPSR1SMN1; SMN2LMNA | |
| SCHEMBL914682 | 0.72 | NPSR1 (0.67) | NPSR1SMN1; SMN2LMNA | |
| SCHEMBL2080679 | 0.72 | NR1H3 (0.56) | SMN1; SMN2RORCNR1H3NR1H2MLYCD | |
| SCHEMBL14467691 | 0.72 | NPSR1 (0.67) | NPSR1SMN1; SMN2LMNA | |
| SCHEMBL1893010 | 0.71 | NPSR1 (1.00) | NPSR1LMNANR1I2 | |
| SCHEMBL28660587 | 0.70 | NPSR1 (0.65) | NPSR1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070869-A1 | Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-03-20 | — | — | US | disclosed |
| US-20080070869-A1 | Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-03-20 | — | — | US | disclosed |
| US-7279477-B2 | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-10-09 | — | — | US | disclosed |
| US-7279477-B2 | Malonyl-CoA decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2007-10-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080070869-A1 | Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | MLYCD, ME3, ACACA | NPSR1 4820/4885SMN1; SMN2 2783/4885RORC 1595/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.