Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | RORC | P51449 | 4/20 | 0.54 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.47 |
| ▸ | MLYCD | O95822 | 3/20 | 0.46 |
| ▸ | RORA | P35398 | 3/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.44 |
| ▸ | RORB | Q92753 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
| ▸ | PGK2 | P07205 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14255602 | 0.77 | NPSR1 (0.54) | SMN1; SMN2RORCNR1H3MLYCDRORA | |
| SCHEMBL131990 | 0.74 | NR1H2 (0.68) | SMN1; SMN2NR1H3MLYCDNR1H2 | |
| SCHEMBL4882316 | 0.73 | NR1H3 (0.50) | SMN1; SMN2RORCNR1H3MLYCDNR1H2 | |
| SCHEMBL6487024 | 0.72 | SMN1; SMN2 (0.61) | SMN1; SMN2RORCNR1H3MLYCDRORA | |
| SCHEMBL19112729 | 0.72 | SMN1; SMN2 (0.56) | SMN1; SMN2RORCNR1H3MLYCDRORA | |
| Water SCHEMBL1684070 | 0.72 | NR1H2 (0.65) | SMN1; SMN2NR1H3MLYCDNR1H2 | |
| SCHEMBL2944332 | 0.72 | NR1H3 (0.66) | SMN1; SMN2RORCNR1H3MLYCDRORA | |
| SCHEMBL3434346 | 0.72 | SMN1; SMN2 (0.71) | SMN1; SMN2RORCNR1H3MLYCDRORA | |
| SCHEMBL2081375 | 0.70 | SMN1; SMN2 (1.00) | SMN1; SMN2RORCMLYCDRORARORB | |
| SCHEMBL11626027 | 0.70 | SMN1; SMN2 (0.69) | SMN1; SMN2RORCMLYCDRORAEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080070869-A1 | Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2008-03-20 | — | — | US | disclosed |
| US-20040063671-A1 | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2004-04-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040063671-A1 | Malonyl-coa decarboxylase inhibitors useful as metabolic modulators | MLYCD, ACACA, ME1 | SMN1; SMN2 2729/4885RORC 1674/4885NR1H3 1471/4885 |
| US-20080070869-A1 | Malonyl-CoA Decarboxylase Inhibitors Useful as Metabolic Modulators | MLYCD, ME3, ACACA | SMN1; SMN2 2783/4885RORC 1595/4885NR1H3 1405/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.