Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2982317 | 1.00 | NR1H2 (0.53) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL21845511 | 0.95 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL13940144 | 0.92 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL12539048 | 0.92 | NR1H2 (0.49) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL894282 | 0.86 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL14303506 | 0.83 | NR1H2 (0.57) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL17274163 | 0.83 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL22712718 | 0.83 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL19024156 | 0.83 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2NAMPTHPGD | |
| SCHEMBL19024158 | 0.83 | NR1H2 (0.50) | NR1H2USP2SMN1; SMN2NAMPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112679411-B | Preparation method of chiral 5- (methylamino) hexahydrocyclopenta [ c ] pyrrole-2 (1H) -Boc methanesulfonate | 上海再启生物技术有限公司 | 2022-04-01 | — | — | CN | claimed |
| CN-112679411-A | Preparation method of chiral 5- (methylamino) hexahydrocyclopenta [ c ] pyrrole-2 (1H) -Boc methanesulfonate | 上海再启生物技术有限公司 | 2021-04-20 | — | — | CN | claimed |
| CN-112679411-B | Preparation method of chiral 5- (methylamino) hexahydrocyclopenta [ c ] pyrrole-2 (1H) -Boc methanesulfonate | 上海再启生物技术有限公司 | 2022-04-01 | — | — | CN | disclosed |
| CN-112679411-A | Preparation method of chiral 5- (methylamino) hexahydrocyclopenta [ c ] pyrrole-2 (1H) -Boc methanesulfonate | 上海再启生物技术有限公司 | 2021-04-20 | — | — | CN | disclosed |
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2020-09-29 | — | — | US | disclosed |
| US-10421720-B2 | Octahydrocyclopentapyrroles, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-09-24 | — | — | US | disclosed |
| US-20180298012-A1 | OCTAHYDROPYRROLOPYRROLES THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-10-18 | — | — | US | disclosed |
| US-20180237391-A1 | OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-08-23 | — | — | US | disclosed |
| EP-2968303-B1 | OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE | UNIV COLUMBIA (US) | 2018-07-04 | — | — | EP | disclosed |
| US-9944644-B2 | Octahydropyrrolopyrroles their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-04-17 | — | — | US | disclosed |
| US-9926271-B2 | Octahydrocyclopentapyrroles, their preparation and use | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-03-27 | — | — | US | disclosed |
| US-8481524-B2 | c-MET protein kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-07-09 | — | — | US | disclosed |
| US-8198296-B2 | Sub-type selective azabicycloalkane derivatives | TARGACEPT, INC. (US) | 2012-06-12 | — | — | US | disclosed |
| US-20110136789-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-09 | — | — | US | disclosed |
| US-20110136789-A1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2011-06-09 | — | — | US | disclosed |
| EP-2205589-B1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2011-03-23 | — | — | EP | disclosed |
| EP-2205589-B1 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMA (US) | 2011-03-23 | — | — | EP | disclosed |
| US-20100173968-A1 | SUB-TYPE SELECTIVE AZABICYCLOALKANE DERIVATIVES | TARGACEPT, INC. (US) | 2010-07-08 | — | — | US | disclosed |
| WO-2009045992-A2 | C-MET PROTEIN KINASE INHIBITORS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-04-09 | — | — | WO | disclosed |
| US-20060287290-A1 | Azabicyclic compounds are central nervous system active agents | DART MICHAEL J | 2006-12-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110136789-A1 | C-MET PROTEIN KINASE INHIBITORS | MET, PRKCH, ABL1 | NR1H2 2477/4885USP2 2356/4885SMN1; SMN2 3535/4885 |
| US-20180237391-A1 | OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE | CLN6, ALDH1A2, C1S | NR1H2 87/4885USP2 3823/4885SMN1; SMN2 1454/4885 |
| US-20100173968-A1 | SUB-TYPE SELECTIVE AZABICYCLOALKANE DERIVATIVES | CHRNB2, CHRNB4, CHRNA4 | NR1H2 583/4885USP2 3288/4885SMN1; SMN2 228/4885 |
| US-20180298012-A1 | OCTAHYDROPYRROLOPYRROLES THEIR PREPARATION AND USE | QDPR, DPYD, DHPS | NR1H2 2078/4885USP2 3927/4885SMN1; SMN2 2790/4885 |
| US-10421720-B2 | Octahydrocyclopentapyrroles, their preparation and use | CLN6, ALDH1A2, C1S | NR1H2 87/4885USP2 3823/4885SMN1; SMN2 1454/4885 |
| US-20060287290-A1 | Azabicyclic compounds are central nervous system active agents | ACHE, CHAT, CHRNA6 | NR1H2 570/4885USP2 3564/4885SMN1; SMN2 191/4885 |
| US-10787453-B2 | Octahydropyrrolopyrroles their preparation and use | QDPR, DPYD, DHPS | NR1H2 2078/4885USP2 3927/4885SMN1; SMN2 2790/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.