Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.54 |
| ▸ | DNM1 | Q05193 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | PRKCA | P17252 | 1/20 | 0.47 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.47 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
| ▸ | DGKA | P23743 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8396305 | 1.00 | LMNA (0.62) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL8394182 | 1.00 | LMNA (0.62) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL872500 | 1.00 | LMNA (0.62) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL465982 | 1.00 | LMNA (0.62) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL8394932 | 1.00 | LMNA (0.62) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL15228719 | 1.00 | LMNA (0.62) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL8394166 | 0.98 | LMNA (0.59) | LMNAMAPTMAPK1DNM1ALDH1A1 | |
| SCHEMBL992184 | 0.91 | PRKCA (0.54) | LMNAMAPTALDH1A1PRKCAPRKCE | |
| SCHEMBL465985 | 0.91 | PRKCA (0.54) | LMNAMAPTALDH1A1PRKCAPRKCE | |
| SCHEMBL31374704 | 0.87 | ALDH1A1 (0.58) | LMNAMAPTALDH1A1PRKCAPRKCE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11246932-B2 | Prostaglandin compositions and methods for the treatment of vasospasm | NEXMED HOLDINGS, INC. (US) | 2022-02-15 | — | — | US | disclosed |
| US-20190076529-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | NEXMED HOLDINGS, INC. (US) | 2019-03-14 | — | — | US | disclosed |
| US-20150272875-A1 | ALPROSTADIL FOR TREATMENT OF PREMATURE EJACULATION | NEXMED HOLDINGS, INC. (US) | 2015-10-01 | — | — | US | disclosed |
| US-9066854-B2 | Alprostadil and dyclonine for treatment of premature ejaculation | NEXMED HOLDINGS, INC. (US) | 2015-06-30 | — | — | US | disclosed |
| US-9060929-B2 | Alprostadil for treatment of premature ejaculation | NEXMED HOLDINGS, INC. (US) | 2015-06-23 | — | — | US | disclosed |
| US-9056044-B2 | Alprostadil and lidocaine treatment of premature ejaculation | NEXMED HOLDINGS, INC. (US) | 2015-06-16 | — | — | US | disclosed |
| US-20150011587-A1 | ALPROSTADIL FOR TREATMENT OF PREMATURE EJACULATION | NEXMED HOLDINGS, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011638-A1 | ALPROSTADIL AND LIDOCAINE TREATMENT OF PREMATURE EJACULATION | NEXMED HOLDINGS, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-20150011585-A1 | ALPROSTADIL AND DYCLONINE FOR TREATMENT OF PREMATURE EJACULATION | NEXMED HOLDINGS, INC. (US) | 2015-01-08 | — | — | US | disclosed |
| US-8841345-B2 | Compositions and methods for treatment of premature ejaculation | NEXMED HOLDINGS, INC. (US) | 2014-09-23 | — | — | US | disclosed |
| US-20140206766-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | NEXMED HOLDINGS, INC. (US) | 2014-07-24 | — | — | US | disclosed |
| US-20140142188-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | NEXMED HOLDINGS, INC. (US) | 2014-05-22 | — | — | US | disclosed |
| US-8632813-B2 | Prostaglandin compositions and methods for the treatment of vasospasm | NEXMED (HOLDINGS), INC. (US) | 2014-01-21 | — | — | US | disclosed |
| US-20080069883-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | NEXMED HOLDINGS, INC. (US) | 2008-03-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150011638-A1 | ALPROSTADIL AND LIDOCAINE TREATMENT OF PREMATURE EJACULATION | LPXN, LMNB1, PLA2G10 | LMNA 5/4885MAPT 1713/4885MAPK1 2568/4885 |
| US-20190076529-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | PTGIS, PTGIR, PGF | LMNA 2078/4885MAPT 3730/4885MAPK1 4752/4885 |
| US-20140142188-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | PTGIS, PTGIR, PGF | LMNA 2078/4885MAPT 3730/4885MAPK1 4752/4885 |
| US-20150011587-A1 | ALPROSTADIL FOR TREATMENT OF PREMATURE EJACULATION | PTGER1, PLA2G10, PDE12 | LMNA 42/4885MAPT 1502/4885MAPK1 2871/4885 |
| US-20140206766-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | PTGIS, PTGIR, PGF | LMNA 2078/4885MAPT 3730/4885MAPK1 4752/4885 |
| US-11246932-B2 | Prostaglandin compositions and methods for the treatment of vasospasm | PTGIS, PTGIR, PGF | LMNA 2078/4885MAPT 3730/4885MAPK1 4752/4885 |
| US-20080069883-A1 | PROSTAGLANDIN COMPOSITIONS AND METHODS FOR THE TREATMENT OF VASOSPASM | PTGIS, PTGIR, PGF | LMNA 2078/4885MAPT 3730/4885MAPK1 4752/4885 |
| US-20150011585-A1 | ALPROSTADIL AND DYCLONINE FOR TREATMENT OF PREMATURE EJACULATION | DAGLA, PHOSPHO1, PLD1 | LMNA 143/4885MAPT 414/4885MAPK1 1470/4885 |
| US-20150272875-A1 | ALPROSTADIL FOR TREATMENT OF PREMATURE EJACULATION | PTGER1, PLA2G10, PDE12 | LMNA 42/4885MAPT 1502/4885MAPK1 2871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.