SCHEMBL1426756

SCHEMBL1426756

CC(=O)Cc1cccc(F)c1

nearest known ligand 0.62

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
MAOB P27338 4/20 0.51
IDO1 P14902 2/20 0.50
AGXT P21549 2/20 0.50
GFER P55789 1/20 0.48
MAOA P21397 1/20 0.48
TAAR1 Q96RJ0 3/20 0.47
RIPK1 Q13546 1/20 0.46
SLC1A1 P43005 2/20 0.46
CASP3 P42574 1/20 0.46
CASP7 P55210 1/20 0.46
MAPK8 P45983 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2209416 0.85 VNN1 (0.49) MAOBMAOATAAR1MAPK8
SCHEMBL6509671 0.85 ALDH1A1 (0.46)
SCHEMBL6864466 0.83 TAAR1 (0.50) MAOBIDO1AGXTTAAR1SLC1A1
SCHEMBL3025521 0.83 TAAR1 (0.50) MAOBIDO1AGXTMAOATAAR1
SCHEMBL9113 0.82 AKR1B1 (0.58) TAAR1SLC1A1
SCHEMBL8498964 0.81 VNN1 (0.48) MAOBTAAR1RIPK1SLC1A1CASP3
SCHEMBL2290 0.81 ALDH1A1 (0.60) MAOBMAOATAAR1CASP3CASP7
SCHEMBL2304146 0.80 AGXT (0.57) AGXT
SCHEMBL1149255 0.80 TAAR1 (0.47) IDO1AGXTTAAR1SLC1A1CASP3
Hydrochloric Acid SCHEMBL2531929 0.80 AKR1B1 (0.56) IDO1AGXTTAAR1SLC1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 162 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114950159-B Preparation method of aromatic polymer separation membrane based on super acid catalysis 南京工业大学 2023-06-06 CN claimed
CN-120058445-A Method for generating aryl phenol compound by hydroxylation of uranium photocatalytic aryl fluorine compound and application of method 华东师范大学 2025-05-30 CN disclosed
CN-118879823-A Synthesis method of (R) -3-halogenated phenylpropanol 四川新迪生物制药有限公司 2024-11-01 CN disclosed
US-12084436-B2 Heterocyclic compound TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2024-09-10 US disclosed
US-12084462-B2 Spiro bicyclic inhibitors of menin-MLL interaction JANSSEN PHARMACEUTICA NV (BE) 2024-09-10 US disclosed
US-20240226305-A1 COMPOUNDS FOR TREATMENT OF TYPE 2 DIABETES ELMALEH DAVID R (US) 2024-07-11 US disclosed
WO-2024050825-A1 COMPOUNDS AS MLKL INHIBITORS NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES, BEIJING (CN) 2024-03-14 WO disclosed
EP-3521289-B1 MNK INHIBITORS AND METHODS RELATED THERETO EFFECTOR THERAPEUTICS INC (US) 2023-10-25 EP disclosed
WO-2023114379-A1 PLPRO INHIBITORS HUAHAI US INC. (US) 2023-06-22 WO disclosed
EP-4132938-A1 SUBSTITUTED THIAZOLOPYRIDINES, SALTS THEREOF AND THEIR USE AS HERBICIDALLY ACTIVE SUBSTANCES Bayer Aktiengesellschaft (DE) 2023-02-15 EP disclosed
WO-2003080625-A1 THIOPYRIMIDINE AND ISOTHIAZOLOPYRIMIDINE KINASE INHIBITORS ABBOTT LABORATORIES (US) 2003-10-02 WO disclosed
CN-1433972-A Process for degrading organic fluoride from waste water by photocatalysis JIANGSU ACADEMY OF ENVIRONMENT (CN) 2003-08-06 CN disclosed
EP-1261600-A1 HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 AstraZeneca AB (SE) 2002-12-04 EP disclosed
US-20020107252-A1 Novel Compounds ASTRAZENECA AB (SE) 2002-08-08 US disclosed
WO-2001058890-A1 HETEROAROMATIC CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 ASTRAZENECA AB (SE) 2001-08-16 WO disclosed
US-4487969-A DIAZOTIZATION OF M-AMINOACETOPHENONE FOLLOWED BY HEAT DECOMPOSITION OLIN CORPORATION (US) 1984-12-11 US disclosed
EP-0105641-A1 Production of m-fluoroacetophenone OLIN CORPORATION (US) 1984-04-18 EP disclosed
US-4393004-A DUIRETICS AMERICAN CYANAMID COMPANY (US) 1983-07-12 US disclosed
US-4340734-A DIURETICS AMERICAN CYANAMID COMPANY (US) 1982-07-20 US disclosed
US-4325955-A DIURETICS AMERICAN CYANAMID COMPANY (US) 1982-04-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12084462-B2 Spiro bicyclic inhibitors of menin-MLL interaction BMI1, MLLT1, MEN1 MAOB 4301/4885IDO1 3852/4885AGXT 4004/4885
US-12084436-B2 Heterocyclic compound HDAC1, HDAC5, HDAC6 MAOB 340/4885IDO1 1525/4885AGXT 1755/4885
US-20020107252-A1 Novel Compounds UGT1A1, CYP1B1, CYP1A1 MAOB 337/4885IDO1 238/4885AGXT 989/4885
US-20240226305-A1 COMPOUNDS FOR TREATMENT OF TYPE 2 DIABETES SLC5A2, GPR119, GLP1R MAOB 562/4885IDO1 1541/4885AGXT 630/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.