Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 8/20 | 0.51 |
| ▸ | TYMS | P04818 | 4/20 | 0.51 |
| ▸ | ATIC | P31939 | 3/20 | 0.51 |
| ▸ | GART | P22102 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | TLR4 | O00206 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | FOLR2 | P14207 | 1/20 | 0.51 |
| ▸ | FOLR1 | P15328 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28801046 | 0.88 | DHFR (0.52) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL5053297 | 0.86 | DHFR (0.54) | DHFRTYMSATICGARTKDM4E | |
| Methopterine SCHEMBL2274614 | 0.85 | DHFR (0.69) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL25167471 | 0.85 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL5549456 | 0.85 | DHFR (0.53) | DHFRTYMSATICGARTKDM4E | |
| Methopterine SCHEMBL246803 | 0.85 | DHFR (0.70) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL338037 | 0.84 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL16653871 | 0.84 | DHFR (0.54) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL29190442 | 0.84 | DHFR (0.57) | DHFRTYMSATICGARTKDM4E | |
| SCHEMBL28344203 | 0.84 | DHFR (0.61) | DHFRTYMSATICGARTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8735439-B2 | Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same | DIATECH KOREA CO., LTD. (KR) | 2014-05-27 | — | — | US | claimed |
| EP-2431366-A1 | NEW CHLORINE E6-FOLIC ACID CONJUGATED COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATMENT OF CANCER | Diatech Korea Co., Ltd. (KR) | 2012-03-21 | — | — | EP | claimed |
| US-20120059018-A1 | NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME | DIATECH KOREA CO., LTD. (KR) | 2012-03-08 | — | — | US | claimed |
| US-8735439-B2 | Chlorin e6-folic acid conjugate, preparation method thereof, and a pharmaceutical composition for the treatment of cancer comprising the same | DIATECH KOREA CO., LTD. (KR) | 2014-05-27 | — | — | US | disclosed |
| EP-2431366-A1 | NEW CHLORINE E6-FOLIC ACID CONJUGATED COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATMENT OF CANCER | Diatech Korea Co., Ltd. (KR) | 2012-03-21 | — | — | EP | disclosed |
| EP-2431040-A1 | PHARMACEUTICAL COMPOSITION COMPRISING CHLORINE E6-FOLIC ACID CONJUGATED COMPOUND AND CHITOSAN FOR TREATMENT OF CANCER | Diatech Korea Co., Ltd. (KR) | 2012-03-21 | — | — | EP | disclosed |
| US-20120059018-A1 | NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME | DIATECH KOREA CO., LTD. (KR) | 2012-03-08 | — | — | US | disclosed |
| US-20120035180-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING CHLORIN E6-FOLIC ACID CONJUGATE COMPOUND AND CHITOSAN | DIATECH KOREA CO., LTD. (KR) | 2012-02-09 | — | — | US | disclosed |
| WO-2010126178-A1 | NEW CHLORINE E6-FOLIC ACID CONJUGATED COMPOUND, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME FOR TREATMENT OF CANCER | 다이아텍코리아 주식회사 (KR) | 2010-11-04 | — | — | WO | disclosed |
| WO-2010126179-A1 | PHARMACEUTICAL COMPOSITION COMPRISING CHLORINE E6-FOLIC ACID CONJUGATED COMPOUND AND CHITOSAN FOR TREATMENT OF CANCER | 다이아텍코리아 주식회사 (KR) | 2010-11-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120035180-A1 | PHARMACEUTICAL COMPOSITION FOR TREATING CANCER COMPRISING CHLORIN E6-FOLIC ACID CONJUGATE COMPOUND AND CHITOSAN | FOLR1, FOLR2, SLC46A1 | DHFR 4/4885TYMS 20/4885ATIC 1635/4885 |
| US-20120059018-A1 | NOVEL CHLORIN E6-FOLIC ACID CONJUGATE, PREPARATION METHOD THEREOF, AND A PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF CANCER COMPRISING THE SAME | FOLR1, FOLR2, DHFR | DHFR 3/4885TYMS 21/4885ATIC 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.