Methopterine

Methopterine

SCHEMBL246803

CN(Cc1cnc2[nH]c(N)nc(=O)c2n1)c1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1

nearest known ligand 0.70

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DHFR P00374 5/20 0.70
TYMS P04818 3/20 0.70
FPGS Q05932 3/20 0.70
KDM4E B2RXH2 2/20 0.70
MEN1 O00255 2/20 0.70
ALDH1A1 P00352 2/20 0.70
POLB P06746 2/20 0.70
HPGD P15428 2/20 0.70
KMT2A Q03164 2/20 0.70
HSD17B10 Q99714 2/20 0.70
TDP1 Q9NUW8 2/20 0.70
TLR4 O00206 1/20 0.70
LMNA P02545 1/20 0.70
TP53 P04637 1/20 0.70
GLA P06280 1/20 0.70
HMGB1 P09429 1/20 0.70
MAPT P10636 1/20 0.70
FOLR2 P14207 1/20 0.70
FOLR1 P15328 1/20 0.70
ALOX15 P16050 1/20 0.70

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methopterine SCHEMBL2274614 0.99 DHFR (0.69) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL338037 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL29190442 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL25167471 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL28344641 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL16583122 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL869876 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL28135233 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL20486467 0.91 DHFR (0.57) DHFRTYMSFPGSKDM4EMEN1
SCHEMBL3771709 0.90 DHFR (0.56) DHFRTYMSFPGSKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 653 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250099401-A1 Hemp Oil/Magnesium Preparation for Cognitive-Enhancement and Reduction of Stress and lnflammation FP NUTRACEUTICALS, LLC (US) 2025-03-27 US claimed
CN-119679799-A Folic acid-containing composition, application thereof, orally disintegrating tablet and preparation method 北京斯利安药业有限公司 2025-03-25 CN claimed
US-20250090455-A1 SACCHARIDE-BASED ORAL MUCOADHESIVE DELIVERY SYSTEM FOR NUTRITIONAL AND NUTRACEUTICAL COMPOSITIONS FP NUTRACEUTICALS, LLC (US) 2025-03-20 US claimed
US-12201623-B1 Composition and method for preventing long-term COVID-19 morbidity KLIPPER, MICHAEL 2025-01-21 US claimed
US-20240285704-A1 COMPOSITIONS COMPRISING ORGANIC MINERAL CHELATES, NIACINAMIDE, AND HEMP OIL AND USES THEREOF FOR NEUROPROTECTION, CARDIOPROTECTION, DETOXIFICATION, IMMUNE SUPPORT, AND ANTI-AGING HANCOCK WHITNEY BANK 2024-08-29 US claimed
US-20240277750-A1 COMPOSITIONS AND METHODS FOR TREATING DEPRESSION HedoniaUSA, Ave (US) 2024-08-22 US claimed
CN-114344328-B Composition for reducing gout occurrence risk of hypertensive patient 深圳奥萨制药有限公司 2024-01-16 CN claimed
CN-117297101-A Composite nutritional supplement, preparation method and application thereof 淄博维克勋医药技术有限公司 2023-12-29 CN claimed
US-20230372241-A1 SACCHARIDE-BASED ORAL MUCOADHESIVE DELIVERY SYSTEM FOR NUTRITIONAL AND NUTRACEUTICAL COMPOSITIONS FP NUTRACEUTICALS, LLC (US) 2023-11-23 US claimed
US-20230372265-A1 Hemp Oil/Magnesium Preparation for Cognitive-Enhancement and Reduction of Stress and lnflammation FP NUTRACEUTICALS, LLC (US) 2023-11-23 US claimed
US-20090325949-A1 5 HT RECEPTOR MEDIATED NEUROGENESIS BRAINCELLS, INC. (US) 2009-12-31 US claimed
EP-1501551-B1 Folate-receptor targeted imaging agents ENDOCYTE INC (US) 2009-11-18 EP claimed
EP-2026813-A2 5 HT RECEPTOR MEDIATED NEUROGENESIS Braincells, Inc. (US) 2009-02-25 EP claimed
US-20070270449-A1 5 HT RECEPTOR MEDIATED NEUROGENESIS BRAINCELLS, INC. (US) 2007-11-22 US claimed
WO-2007134077-A2 5 HT RECEPTOR MEDIATED NEUROGENESIS BRAINCELLS, INC. (US) 2007-11-22 WO claimed
EP-0724447-B1 DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE ISIS PHARMACEUTICALS INC (US) 2003-05-07 EP claimed
US-20020177150-A1 Derivatized oligonucleotides having improved uptake and other properties ISIS PHARMACEUTICAL, INC. 2002-11-28 US claimed
EP-0724447-A1 DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES ISIS PHARMACEUTICALS, INC. (US) 1996-08-07 EP claimed
EP-0724447-A4 DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES ISIS PHARMACEUTICALS INC (US) 1996-01-22 EP claimed
WO-1993007883-A1 DERIVATIZED OLIGONUCLEOTIDES HAVING IMPROVED UPTAKE AND OTHER PROPERTIES ISIS PHARMACEUTICALS, INC. (US) 1993-04-29 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070270449-A1 5 HT RECEPTOR MEDIATED NEUROGENESIS HTR5A, HTR6, GAP43 DHFR 413/4885TYMS 1003/4885FPGS 637/4885
US-20090325949-A1 5 HT RECEPTOR MEDIATED NEUROGENESIS HTR5A, HTR6, GAP43 DHFR 413/4885TYMS 1003/4885FPGS 637/4885
US-20240285704-A1 COMPOSITIONS COMPRISING ORGANIC MINERAL CHELATES, NIACINAMIDE, AND HEMP OIL AND USES THEREOF FOR NEUROPROTECTION, CARDIOPROTECTION, DETOXIFICATION, IMMUNE SUPPORT, AND ANTI-AGING HAMP, NAMPT, FABP3 DHFR 1977/4885TYMS 2471/4885FPGS 668/4885
US-20240277750-A1 COMPOSITIONS AND METHODS FOR TREATING DEPRESSION BHMT2, MAT1A, MGMT DHFR 12/4885TYMS 108/4885FPGS 31/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.