Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 5/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PLK1 | P53350 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10205950 | 0.91 | PLK1 (0.54) | HTTCYP2C9PLK1TSHRNPC1 | |
| SCHEMBL14280204 | 0.85 | MAPT (0.46) | HTTCYP2C9MAPK1PLK1TSHR | |
| SCHEMBL438258 | 0.83 | ALDH1A1 (0.62) | HTTMAPK1PLK1SMN1; SMN2NPC1 | |
| SCHEMBL15694845 | 0.80 | HTT (0.59) | HTTCYP2C9MAPK1PLK1TSHR | |
| SCHEMBL5010875 | 0.77 | MAPK1 (0.59) | HTTCYP2C9MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL12345589 | 0.76 | HTT (0.59) | HTTCYP2C9MAPK1PLK1TSHR | |
| SCHEMBL435644 | 0.75 | RXRA (0.58) | MAPK1PLK1SMN1; SMN2THRBALDH1A1 | |
| SCHEMBL5012548 | 0.75 | CYP2C9 (0.54) | HTTCYP2C9MAPK1PLK1TSHR | |
| SCHEMBL13997263 | 0.75 | HTT (0.54) | HTTCYP2C9MAPK1PLK1TSHR | |
| SCHEMBL5605369 | 0.75 | APP (0.64) | HTTCYP2C9MAPK1TSHRSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031034-A2 | THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |