Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | PLK1 | P53350 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.43 |
| ▸ | PKM | P14618 | 2/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MYC | P01106 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | HAO1 | Q9UJM8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14280209 | 0.85 | HTT (0.55) | MAPTALDH1A1PLK1HTTPKM | |
| SCHEMBL438258 | 0.84 | ALDH1A1 (0.62) | MAPTALDH1A1PLK1HTTPKM | |
| SCHEMBL10205950 | 0.83 | PLK1 (0.54) | ALDH1A1PLK1HTTCYP2C9HPGD | |
| SCHEMBL437676 | 0.73 | ALDH1A1 (0.67) | MAPTALDH1A1PLK1HTTPKM | |
| SCHEMBL435644 | 0.71 | RXRA (0.58) | MAPTALDH1A1PLK1SMN1; SMN2CHRNA7 | |
| SCHEMBL437666 | 0.70 | L3MBTL1 (0.49) | MAPTALDH1A1PLK1CHRNA7PTGS2 | |
| SCHEMBL438115 | 0.70 | TDP1 (0.58) | MAPTALDH1A1PLK1PKMHPGD | |
| SCHEMBL20198486 | 0.69 | AVPR1A (0.61) | MAPTALDH1A1HPGDKDM4ELMNA | |
| SCHEMBL4502407 | 0.68 | SMN1; SMN2 (0.60) | MAPTALDH1A1HPGDKDM4ESMN1; SMN2 | |
| SCHEMBL266136 | 0.68 | PLK1 (0.55) | MAPTALDH1A1PLK1HTTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008031034-A2 | THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS | MYRIAD GENETICS, INC. (US) | 2008-03-13 | — | — | WO | disclosed |