Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.46 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4257154 | 0.79 | SETD7 (0.56) | ALDH1A1CHRM3SETD7OPRM1OPRD1 | |
| SCHEMBL14282961 | 0.79 | ALDH1A1 (0.54) | KDM4EALDH1A1SMN1; SMN2HTTKMT2A | |
| SCHEMBL11036336 | 0.77 | SETD7 (0.53) | ALDH1A1SETD7OPRM1OPRD1OPRK1 | |
| SCHEMBL12890282 | 0.76 | ALDH1A1 (0.70) | NPC1KDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL7437164 | 0.75 | CHRM5 (0.62) | NPC1KDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL14282904 | 0.74 | OPRD1 (0.50) | KDM4EALDH1A1KMT2AL3MBTL1SETD7 | |
| SCHEMBL23464917 | 0.74 | CHRM5 (0.75) | NPC1KDM4EALDH1A1SMN1; SMN2TDP1 | |
| SCHEMBL14198385 | 0.73 | SETD7 (0.65) | SMN1; SMN2CHRM3SETD7OPRM1OPRD1 | |
| SCHEMBL11033270 | 0.72 | SLC6A9 (0.49) | KMT2ASETD7MEN1OPRM1OPRD1 | |
| SCHEMBL7721235 | 0.72 | CHRM5 (0.72) | NPC1KDM4EALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7317026-B2 | Sleep disorders; side effect reduction ; antihistamine antagonist | HYPNION, INC. (US) | 2008-01-08 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |
| US-7189757-B2 | Treatment of sleep disorders using CNS target modulators | HYPNION, INC. (US) | 2007-03-13 | — | — | US | disclosed |