Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | PER2 | O15055 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.46 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.45 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.42 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.41 |
| ▸ | TUBB | P07437 | 1/20 | 0.41 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.41 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30983123 | 0.83 | SIGMAR1 (0.50) | SIGMAR1KMT2AKEAP1ALDH1A1MEN1 | |
| SCHEMBL14599187 | 0.79 | KMT2A (0.40) | KMT2AALDH1A1MEN1PER2MAPT | |
| SCHEMBL998560 | 0.77 | SIGMAR1 (0.52) | SIGMAR1KMT2AKEAP1ALDH1A1MAPT | |
| Sulfamide SCHEMBL3360909 | 0.77 | CA2 (0.61) | SIGMAR1KMT2AMAPTHTTL3MBTL1 | |
| SCHEMBL7478787 | 0.75 | SIGMAR1 (0.59) | SIGMAR1ALDH1A1MAPTTSHRCYP1A2 | |
| SCHEMBL27586816 | 0.75 | SIGMAR1 (0.46) | SIGMAR1KMT2AKEAP1ALDH1A1MEN1 | |
| SCHEMBL29555314 | 0.74 | SIGMAR1 (0.63) | SIGMAR1ALDH1A1MAPTCA2TSHR | |
| SCHEMBL1683320 | 0.74 | SIGMAR1 (0.63) | SIGMAR1KEAP1ALDH1A1MAPTHPGD | |
| SCHEMBL29364795 | 0.74 | SIGMAR1 (0.63) | SIGMAR1ALDH1A1MAPTCA2TSHR | |
| SCHEMBL27737084 | 0.74 | SIGMAR1 (0.63) | SIGMAR1ALDH1A1MAPTCA2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332506-B2 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2008-02-19 | — | — | US | disclosed |
| US-20070049582-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | WYETH (US) | 2007-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070049582-A1 | Substituted-3-indolyl-4-piperidino-alkyl heterocycles for the treatment of depression | TPH1, TPH2, HTR1A | SIGMAR1 638/4885KMT2A 2004/4885KEAP1 2388/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.