Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NNMT | P40261 | 3/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4718816 | 0.81 | SMN1; SMN2 (0.41) | KMT2AALDH1A1CYP1A2CYP2D6CYP2C19 | |
| SCHEMBL31092300 | 0.78 | KMT2A (0.49) | KMT2ANNMTCASP1ALDH1A1TSHR | |
| SCHEMBL801078 | 0.78 | KMT2A (0.49) | KMT2ANNMTCASP1ALDH1A1TSHR | |
| SCHEMBL30846439 | 0.77 | ALDH1A1 (0.49) | KMT2AALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL574989 | 0.77 | ALDH1A1 (0.49) | KMT2AALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL28290440 | 0.77 | TSHR (0.41) | KMT2AALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL8066780 | 0.76 | ALDH1A1 (0.48) | KMT2ACASP1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL31539724 | 0.76 | TSHR (0.54) | KMT2AALDH1A1TSHRKDM4EPOLB | |
| SCHEMBL801045 | 0.75 | CASP1 (0.54) | KMT2ACASP1ALDH1A1TSHRKDM4E | |
| SCHEMBL9899863 | 0.75 | ALDH1A1 (0.47) | KMT2ACASP1ALDH1A1CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1887007-A2 | Novel compounds | AstraZeneca AB (SE) | 2008-02-13 | — | — | EP | disclosed |
| EP-1625126-B1 | IMIDAZO AND THIAZOLOPYRIDINES AS JAK3 KINASE INHIBITORS | ASTRAZENECA AB (SE) | 2008-01-16 | — | — | EP | disclosed |