Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30069326 | 0.72 | PIK3CA (0.33) | — | |
| SCHEMBL2369513 | 0.68 | PARP1 (0.36) | — | |
| SCHEMBL14321691 | 0.62 | BCHE (0.33) | — | |
| SCHEMBL25321738 | 0.60 | — | — | |
| SCHEMBL19278217 | 0.60 | ALDH1A1 (0.35) | ALDH1A1LMNA | |
| SCHEMBL25320029 | 0.59 | PDE2A (0.33) | ALDH1A1LMNA | |
| SCHEMBL16011544 | 0.59 | CDK8 (0.57) | — | |
| SCHEMBL19268782 | 0.59 | ALDH1A1 (0.34) | ALDH1A1 | |
| SCHEMBL25324020 | 0.58 | PDE2A (0.33) | ALDH1A1LMNA | |
| SCHEMBL30867441 | 0.58 | POLB (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals,. LLC | 2012-12-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | MET, KRAS, VHL | ALDH1A1 62/4885LMNA 4238/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.