Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.36 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2370225 | 0.83 | PARP1 (0.40) | PARP1SLC22A12 | |
| SCHEMBL14321691 | 0.78 | BCHE (0.33) | — | |
| SCHEMBL3990759 | 0.71 | ALDH1A1 (0.42) | — | |
| SCHEMBL19278216 | 0.70 | ABL1 (0.36) | — | |
| SCHEMBL28715835 | 0.69 | SLC22A12 (0.58) | PARP1SLC22A12 | |
| SCHEMBL16475117 | 0.69 | ALDH1A1 (0.35) | — | |
| SCHEMBL3991061 | 0.69 | JMJD6 (0.38) | — | |
| SCHEMBL14321692 | 0.68 | ALDH1A1 (0.30) | — | |
| SCHEMBL31279422 | 0.66 | HTR6 (0.42) | — | |
| SCHEMBL14321207 | 0.66 | HTR6 (0.42) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals,. LLC | 2012-12-27 | — | — | US | disclosed |
| WO-2011109593-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | OSI Pharmaceuticals, LLC (US) | 2011-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120329826-A1 | SUBSTITUTED-5-AMINOPYRROLO/PYRAZOLOPYRIDINES | MET, KRAS, VHL | PARP1 1413/4885PLAU 3931/4885SLC22A12 1167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.