Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 4/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.41 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALPI | P09923 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | XIAP | P98170 | 1/20 | 0.40 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.40 |
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14335054 | 0.78 | KIF11 (0.40) | POLBKMT2ATDP1KIF11GSR | |
| SCHEMBL11544964 | 0.78 | HPGD (0.44) | POLBKMT2ATDP1GSRCYP2C19 | |
| SCHEMBL9130354 | 0.77 | KIF11 (0.39) | POLBKMT2ATDP1KIF11CYP2C19 | |
| SCHEMBL9130364 | 0.77 | SLC1A3 (0.40) | POLBKMT2ATDP1KIF11CYP2C19 | |
| SCHEMBL23695275 | 0.76 | CA2 (0.43) | CYP2C19ALOX5SLC7A5CES2CES1 | |
| SCHEMBL2481473 | 0.76 | ALOX5 (0.44) | POLBKMT2ACYP2C19SLC1A3SLC1A2 | |
| SCHEMBL2030179 | 0.76 | ALOX5 (0.44) | POLBKMT2ACYP2C19SLC1A3SLC1A2 | |
| SCHEMBL3351265 | 0.76 | ALOX5 (0.44) | POLBKMT2ACYP2C19SLC1A3SLC1A2 | |
| SCHEMBL8955402 | 0.76 | NOS2 (0.42) | POLBKMT2ATDP1GSRCYP2C19 | |
| SCHEMBL4640223 | 0.75 | ALOX5 (0.42) | POLBKMT2ACYP2C19SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2723856-A2 | INCORPORATION OF SUBSTITUTED LYSINES INTO POLYPEPTIDES | Medical Research Council (GB) | 2014-04-30 | — | — | EP | disclosed |
| WO-2012175924-A2 | INCORPORATION OF SUBSTITUTED LYSINES INTO POLYPEPTIDES | MEDICAL RESEARCH COUNCIL (GB) | 2012-12-27 | — | — | WO | disclosed |