SCHEMBL1434032

SCHEMBL1434032

Nc1ncnc2c1ncn2[C@@H]1O[C@H](COc2ccccc2)[C@@H](O)[C@H]1O

nearest known ligand 0.72

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ADORA1 P30542 5/20 0.72
SMN1; SMN2 Q16637 3/20 0.69
ADORA3 P0DMS8 2/20 0.69
ADORA2A P29274 2/20 0.69
ADORA2B P29275 2/20 0.69
DPP4 P27487 1/20 0.69
MEN1 O00255 1/20 0.69
SLC28A1 O00337 1/20 0.69
MAP3K7 O43318 1/20 0.69
SLC28A2 O43868 1/20 0.69
GAPDH P04406 1/20 0.69
MAPK1 P28482 1/20 0.69
STAT6 P42226 1/20 0.69
PI4KA P42356 1/20 0.69
KMT2A Q03164 1/20 0.69
PI4K2B Q8TCG2 1/20 0.69
DOT1L Q8TEK3 1/20 0.69
SLC29A1 Q99808 1/20 0.69
PI4K2A Q9BTU6 1/20 0.69
SLC28A3 Q9HAS3 1/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6905464 1.00 ADORA1 (0.72) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL2835895 0.91 METTL3 (0.65) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL2835899 0.91 METTL3 (0.65) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL6907702 0.90 METTL3 (0.70) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL6902192 0.89 ADORA1 (0.62) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL9387983 0.89 ADORA1 (0.66) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL8744184 0.88 ADORA1 (0.66) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL6900365 0.88 ADORA1 (0.70) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL9491623 0.88 ADORA1 (0.67) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B
SCHEMBL2235451 0.87 GSK3A (0.67) ADORA1SMN1; SMN2ADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 65 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US claimed
EP-1424064-B1 Use of adenosin or an adenosin analog to smooth out fine lines OREAL (FR) 2007-06-06 EP claimed
WO-2007042679-A2 COSMETIC COMPOSITION CONTAINING A NON-PHOSPHATE COMPOUND BASED ON ADENOSINE AND A TIGHTENING POLYMER L'OREAL (FR) 2007-04-19 WO claimed
US-20040146474-A1 Method for softening lines and relaxing the skin with adenosine and adenosine analogues L'OREAL (FR) 2004-07-29 US claimed
EP-1424064-A1 Use of adenosin or an adenosin analog to smooth out fine lines L'OREAL (FR) 2004-06-02 EP claimed
US-6316423-B1 ANTIISCHEMIC AGENT, HYPOXIA AND ANOXIA BRAIN DAMAGE THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMANT OF HEALTH AND HUMAN SERVICES 2001-11-13 US claimed
EP-0167567-A1 TREATMENT OF METASTASIS BROWN UNIVERSITY RESEARCH FOUNDATION (US) 1986-01-15 EP claimed
WO-1985002616-A1 TREATMENT OF METASTASIS BROWN UNIVERSITY RESEARCH FOUNDATION (US) 1985-06-20 WO claimed
US-20240024243-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2024-01-25 US disclosed
US-20210251901-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2021-08-19 US disclosed
US-20200316101-A1 APPLICATIONS OF TRIACETYL-3-HYDROXYL PHENYL ADENOSINE IN TREATING VASCULAR INFLAMMATIONS OR IMPROVING VASCULAR ENDOTHELIUM FUNCTIONS Beijing Gushen Life Health Technology Co., Ltd. (CN) 2020-10-08 US disclosed
US-20200121603-A1 Fine Dry Particulate Adenosine Compositions and Topical Formulations Including the Same LABORATORY SKIN CARE, INC. 2020-04-23 US disclosed
EP-2906547-B1 COSMETIC COMPOSITIONS CONTAINING AT LEAST ONE HYDROTROPE AND AT LEAST ONE ACTIVE COMPOUND OREAL (FR) 2019-11-20 EP disclosed
EP-3466433-A1 APPLICATIONS OF TRIACETYL-3-HYDROXYL PHENYL ADENOSINE IN TREATING VASCULAR INFLAMMATIONS OR IMPROVING VASCULAR ENDOTHELIUM FUNCTIONS Jiangsu Tasly Diyi Pharmaceutical Co., Ltd. (CN) 2019-04-10 EP disclosed
US-6258836-B1 FATTY ACID COUPLED TO ANTIAIDS SUBSTANCE, ANTIBIOTIC, CHOLINERGIC AGONIST AND OTHER USES FOR PASSING THE BLOOD BRAIN BARRIER PROTARGA, INC. 2001-07-10 US disclosed
US-6255292-B1 INCREASING CELLULAR CONTRACTIONS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA 2001-07-03 US disclosed
WO-2000024365-A1 TREATMENT OF SKIN WITH ADENOSINE OR ADENOSINE ANALOG UNIVERSITY OF MASSACHUSETTS (US) 2000-05-04 WO disclosed
WO-1996029345-A1 NOVEL INOTROPIC AGENTS THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) 1996-09-26 WO disclosed
EP-0708781-A1 A 3 ADENOSINE RECEPTOR AGONISTS THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, Department of Health and Human Services (US) 1996-05-01 EP disclosed
WO-1995002604-A1 A3 ADENOSINE RECEPTOR AGONISTS THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 1995-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200316101-A1 APPLICATIONS OF TRIACETYL-3-HYDROXYL PHENYL ADENOSINE IN TREATING VASCULAR INFLAMMATIONS OR IMPROVING VASCULAR ENDOTHELIUM FUNCTIONS ADORA2A, LIPG, VCAM1 ADORA1 18/4885SMN1; SMN2 4691/4885ADORA3 10/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.