Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | GRM4 | Q14833 | 3/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14347470 | 0.84 | ALDH1A1 (0.55) | PDE3BPDE3ATSHRMAPK1HSD17B10 | |
| SCHEMBL14374187 | 0.81 | APP (0.46) | APPGRM4PDE3BPDE3ATSHR | |
| SCHEMBL14347476 | 0.73 | ADCY1 (0.45) | ALDH1A1NPC1RAB9AMAOB | |
| SCHEMBL14347463 | 0.72 | PRKDC (0.39) | KDM4EALDH1A1NPC1RAB9A | |
| SCHEMBL10090166 | 0.70 | LMNA (0.61) | GRM4ALDH1A1NPC1MAPTL3MBTL1 | |
| SCHEMBL8251751 | 0.69 | ALDH1A1 (0.44) | HSD17B10KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL22867735 | 0.66 | MAOA (0.69) | NPC1RAB9ABCHEACHE | |
| SCHEMBL14347290 | 0.65 | TDO2 (0.35) | PDE3BPDE3ATSHRMAPK1MAPT | |
| SCHEMBL14374420 | 0.65 | ALDH1A1 (0.55) | PDE3BPDE3AMAPK1HSD17B10KDM4E | |
| SCHEMBL30777906 | 0.65 | MAPT (0.52) | KDM4EALDH1A1NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312211-B2 | Pryanone compounds useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2007-12-25 | — | — | US | disclosed |
| US-7312211-B2 | Pryanone compounds useful as reversible inhibitors of cysteine proteases | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. | 2007-12-25 | — | — | US | disclosed |