Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | POLB | P06746 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14376068 | 0.86 | CYP2C9 (0.34) | ALDH1A1KDM4ELMNACYP2C9LOXL2 | |
| SCHEMBL13195002 | 0.79 | PTGS1 (0.42) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL278964 | 0.78 | LMNA (0.41) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL29738718 | 0.78 | LMNA (0.41) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL14375983 | 0.75 | GLO1 (0.36) | — | |
| SCHEMBL26185630 | 0.75 | FTO (0.47) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL2616432 | 0.74 | CA1 (0.40) | ALDH1A1KDM4ELMNACA1CA2 | |
| SCHEMBL24132435 | 0.73 | KIF11 (0.36) | ALDH1A1KDM4ELMNAKMT2APOLB | |
| SCHEMBL14868350 | 0.73 | ALDH1A1 (0.39) | ALDH1A1KDM4ELMNAKMT2AMEN1 | |
| SCHEMBL19522383 | 0.73 | SCN10A (0.39) | ALDH1A1KDM4ELMNACA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |