Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | IL18 | Q14116 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | RORC | P51449 | 3/20 | 0.45 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.44 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14349323 | 0.86 | LMNA (0.44) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL2033732 | 0.83 | RAB9A (0.56) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL10192058 | 0.81 | NPC1 (0.52) | KMT2ALMNAPOLBPKMRAB9A | |
| SCHEMBL14376088 | 0.80 | SMN1; SMN2 (0.61) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL959690 | 0.80 | EGLN2 (0.55) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL14349237 | 0.79 | RAB9A (0.54) | MAPTKMT2ALMNAMEN1POLB | |
| SCHEMBL13855057 | 0.79 | NLRP3 (0.49) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL6415967 | 0.79 | SMN1; SMN2 (0.56) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL2088691 | 0.79 | PGR (0.62) | MAPTKMT2ALMNAMEN1SAE1 | |
| SCHEMBL14375552 | 0.78 | SMN1; SMN2 (0.56) | MAPTKMT2ALMNAMEN1SAE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |
| US-7312209-B2 | Acridone inhibitors of IMPDH enzyme | BRISTOL-MYERS SQUIBB COMPANY (US) | 2007-12-25 | — | — | US | disclosed |