Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | IL18 | Q14116 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.46 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2323162 | 0.86 | SMN1; SMN2 (0.57) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL2033732 | 0.83 | RAB9A (0.56) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL3580483 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL10192028 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL2322638 | 0.81 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL4421079 | 0.81 | MMP2 (0.46) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL4421076 | 0.81 | MMP2 (0.46) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL20073905 | 0.80 | SMN1; SMN2 (0.51) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 | |
| SCHEMBL14349323 | 0.80 | LMNA (0.44) | LMNAMAPTMAPK1SAE1UBA2 | |
| SCHEMBL14376088 | 0.80 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101014343-A | Tetracyclic lactam derivatives and uses thereof | INOTEK PHARMACEUTICALS CORP (US) | 2007-08-08 | — | — | CN | disclosed |
| US-20050261288-A1 | Tetracyclic lactam derivatives and uses thereof | INOTEK PHARMACEUTICALS CORPORATION | 2005-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050261288-A1 | Tetracyclic lactam derivatives and uses thereof | PARK7, GLS, IAPP | SMN1; SMN2 526/4885LMNA 4269/4885ALDH1A1 1205/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.