Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | IL1RN | P18510 | 1/20 | 0.40 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1728418 | 0.79 | CNR1 (0.59) | MEN1KMT2ALMNACNR1IL1RN | |
| SCHEMBL23111915 | 0.76 | MCHR1 (0.50) | L3MBTL1MEN1KMT2AROCK2CNR1 | |
| SCHEMBL19466166 | 0.76 | ABCC4 (0.58) | LMNA | |
| SCHEMBL2774874 | 0.76 | CNR1 (0.64) | L3MBTL1LMNACNR1RAB9AMCHR1 | |
| SCHEMBL23828908 | 0.74 | ROCK2 (0.62) | ROCK2RAB9AHIF1A | |
| SCHEMBL14466731 | 0.74 | MAOB (0.48) | L3MBTL1KMT2AKDM4E | |
| SCHEMBL16518818 | 0.74 | MAPT (0.43) | LMNARAB9A | |
| SCHEMBL22501787 | 0.74 | L3MBTL1 (0.45) | L3MBTL1MEN1KMT2ALMNAROCK2 | |
| SCHEMBL21904925 | 0.72 | PDPK1 (0.53) | L3MBTL1ERAP2ERAP1 | |
| Hydrochloric Acid SCHEMBL14352973 | 0.72 | MAOB (0.52) | L3MBTL1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9775840-B2 | Peripherally acting opioid compounds | ALKERMES, INC. (US) | 2017-10-03 | — | — | US | disclosed |
| EP-2725908-B1 | PERIPHERALLY ACTING OPIOID COMPOUNDS | ALKERMES INC (US) | 2017-05-31 | — | — | EP | disclosed |
| US-20170007609-A1 | PERIPHERALLY ACTING OPIOID COMPOUNDS | ALKERMES INC (US) | 2017-01-12 | — | — | US | disclosed |
| US-9415045-B2 | Peripherally acting opioid compounds | ALKERMES, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-20150196550-A1 | Peripherally Acting Opioid Compounds | ALKERMES INC (US) | 2015-07-16 | — | — | US | disclosed |
| US-8962646-B2 | Peripherally acting opioid compounds | ALKERMES, INC. (US) | 2015-02-24 | — | — | US | disclosed |
| EP-2725908-A1 | PERIPHERALLY ACTING OPIOID COMPOUNDS | Alkermes, Inc. (US) | 2014-05-07 | — | — | EP | disclosed |
| WO-2013003720-A1 | PERIPHERALLY ACTING OPIOID COMPOUNDS | ALKERMES, INC. (US) | 2013-01-03 | — | — | WO | disclosed |
| US-20130005755-A1 | Peripherally Acting Opioid Compounds | ALKERMES, INC. | 2013-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150196550-A1 | Peripherally Acting Opioid Compounds | OPRM1, OPRK1, OPRL1 | L3MBTL1 3815/4885MEN1 4656/4885KMT2A 3634/4885 |
| US-20170007609-A1 | PERIPHERALLY ACTING OPIOID COMPOUNDS | OPRM1, OPRK1, OPRL1 | L3MBTL1 3815/4885MEN1 4656/4885KMT2A 3634/4885 |
| US-20130005755-A1 | Peripherally Acting Opioid Compounds | OPRM1, OPRK1, OPRL1 | L3MBTL1 3815/4885MEN1 4656/4885KMT2A 3634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.