Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 5/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | PPARD | Q03181 | 2/20 | 0.50 |
| ▸ | PPARA | Q07869 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | KLK7 | P49862 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5266770 | 0.86 | RAB9A (0.64) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5266781 | 0.81 | RAB9A (0.54) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5266878 | 0.77 | ALOX12 (0.48) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL678221 | 0.76 | ALOX15 (0.78) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL10563010 | 0.76 | ALOX12 (0.78) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL19236369 | 0.74 | ALOX12 (0.62) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL2942244 | 0.74 | ALOX12 (0.62) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL4175173 | 0.74 | ALDH1A1 (0.63) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL234545 | 0.72 | ALOX12 (0.51) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 | |
| SCHEMBL5267997 | 0.72 | NPC1 (0.61) | RAB9AKDM4ENPC1SMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1456180-B1 | 3-(2,4)DIHYDROXYPHENYL-4-PHENYLPYRAZOLES AND THEIR MEDICAL USE | VERNALIS CAMBRIDGE LTD (GB) | 2007-10-03 | — | — | EP | disclosed |