SCHEMBL144065

SCHEMBL144065

O=[C]C=CCCc1cccc2ccccc12

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 2/20 0.43
NQO2 P16083 1/20 0.43
TDP1 Q9NUW8 1/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
CYP2C9 P11712 1/20 0.42
MEN1 O00255 1/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
HPGD P15428 1/20 0.41
KMT2A Q03164 1/20 0.41
ACP3 P15309 1/20 0.41
DAO P14920 2/20 0.40
CYP2D6 P10635 2/20 0.40
GPR52 Q9Y2T5 1/20 0.39
CA2 P00918 1/20 0.38
LMNA P02545 1/20 0.38
ADRA2A P08913 1/20 0.38
SLC6A2 P23975 1/20 0.38
SQLE Q14534 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2106557 0.90 MTNR1A (0.42) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL145560 0.83 TDP1 (0.44) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL6001657 0.77 CYP1A2 (0.46) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL9819905 0.77 CYP1A2 (0.46) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL10639766 0.77 CYP1A2 (0.47) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL10639770 0.77 CYP1A2 (0.47) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL143458 0.77 MTNR1A (0.49) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL7948847 0.77 MTNR1A (0.49) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL11392253 0.76 CYP1A2 (0.44) MTNR1ANQO2TDP1CYP1A2CYP2C19
SCHEMBL11392250 0.76 CYP1A2 (0.44) MTNR1ANQO2TDP1CYP1A2CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 536 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20240084308-A1 FIBROTIC TREATMENT MONASH UNIVERSITY (AU) 2024-03-14 US disclosed
US-20240034845-A1 POLYMER PARTICLES QUEENSLAND UNIVERSITY OF TECHNOLOGY (AU) 2024-02-01 US disclosed
EP-3384549-B1 SODIUM-ION ELECTROLYTE COMPOSITION UNIV DEAKIN (AU) 2024-01-17 EP disclosed
US-11834663-B2 Fibrotic treatment MONASH UNIVERSITY (AU) 2023-12-05 US disclosed
US-20230348674-A1 HYDROGELS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2023-11-02 US disclosed
CN-113939544-B non-core-shell polymer particles 悉尼大学 2023-08-22 CN disclosed
CN-116615468-A Polymer particles 昆士兰科技大学 2023-08-18 CN disclosed
EP-4225811-A1 POLYMER PARTICLES Queensland University Of Technology (AU) 2023-08-16 EP disclosed
WO-2023121483-A1 IMMUNOSTIMULATORY COMPOSITIONS VICTORIA LINK LIMITED (NZ) 2023-06-29 WO disclosed
WO-2023102600-A1 SYNTHESIS OF AMPHIPHILIC BLOCK COPOLYMERS AND POLYMERIC NANOFIBERS PRODUCED THEREFROM NEWSOUTH INNOVATIONS PTY LIMITED (AU) 2023-06-15 WO disclosed
EP-0531901-A2 Condensed pyrazole derivatives with interleukin-1 and tumour necrosis factor inhibitory activity FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1993-03-17 EP disclosed
WO-1992018483-A1 QUINOLINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-10-29 WO disclosed
US-5155101-A Tricyclic compounds FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-10-13 US disclosed
EP-0498069-A2 New use of peptide derivative FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-08-12 EP disclosed
WO-1992012154-A1 IMIDAZOTRIAZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-07-23 WO disclosed
WO-1992003438-A1 TRICYCLIC BENZODIAZEPINE DERIVATES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-03-05 WO disclosed
WO-1992002513-A1 HETEROCYCLIC COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-02-20 WO disclosed
US-4981847-A Tricyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-01-01 US disclosed
EP-0360079-A1 Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-03-28 EP disclosed
EP-0336230-A2 Cyclic peptide antagonists of Substance P and Substance K FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11834663-B2 Fibrotic treatment MMP1, ENPEP, RNPEP MTNR1A 1398/4885NQO2 3834/4885TDP1 3735/4885
US-20230348674-A1 HYDROGELS PHYKPL, TST, PHOSPHO1 MTNR1A 4090/4885NQO2 2360/4885TDP1 2333/4885
US-20240084308-A1 FIBROTIC TREATMENT MMP1, ENPEP, RNPEP MTNR1A 1398/4885NQO2 3834/4885TDP1 3735/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.