SCHEMBL145560

SCHEMBL145560

O=[C]C=CCc1cccc2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 1/20 0.44
CYP1A2 P05177 3/20 0.44
CYP2C19 P33261 2/20 0.44
CYP2C9 P11712 1/20 0.44
HPGD P15428 2/20 0.44
ALDH1A1 P00352 2/20 0.44
MAPT P10636 2/20 0.44
MEN1 O00255 1/20 0.44
KMT2A Q03164 1/20 0.44
ACP3 P15309 1/20 0.43
CYP2D6 P10635 2/20 0.42
HTT P42858 1/20 0.40
CA2 P00918 1/20 0.40
SLC6A2 P23975 2/20 0.40
SIGMAR1 Q99720 2/20 0.40
LMNA P02545 1/20 0.40
ADRA2A P08913 1/20 0.40
SQLE Q14534 1/20 0.40
GAA P10253 1/20 0.40
HSD17B10 Q99714 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL144065 0.83 MTNR1A (0.43) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL2106557 0.80 MTNR1A (0.42) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL143959 0.78 TDP1 (0.47) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL145561 0.76 TDP1 (0.46) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL1611481 0.76 CYP2C19 (0.50) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL6694933 0.76 CYP1A2 (0.48) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL301409 0.76 CYP2C19 (0.48) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL2136855 0.76 CYP2C19 (0.50) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL10499434 0.76 CYP1A2 (0.48) TDP1CYP1A2CYP2C19CYP2C9HPGD
SCHEMBL4229398 0.76 CYP2C19 (0.48) TDP1CYP1A2CYP2C19CYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 683 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7375081-B2 Therapeutic combination of a pneumocandin derivative and an antifungal agent ASTELLAS PHARMA INC. (JP) 2008-05-20 US claimed
US-6875740-B1 Combination of a cyclic hexapeptide with antifungal drugs for treatment of fungal pathogens FUJISAWA PHARMACEUTICAL CO. LTD. (JP) 2005-04-05 US claimed
US-20240084308-A1 FIBROTIC TREATMENT MONASH UNIVERSITY (AU) 2024-03-14 US disclosed
US-20240034845-A1 POLYMER PARTICLES QUEENSLAND UNIVERSITY OF TECHNOLOGY (AU) 2024-02-01 US disclosed
EP-3384549-B1 SODIUM-ION ELECTROLYTE COMPOSITION UNIV DEAKIN (AU) 2024-01-17 EP disclosed
US-11834663-B2 Fibrotic treatment MONASH UNIVERSITY (AU) 2023-12-05 US disclosed
US-20230348674-A1 HYDROGELS COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2023-11-02 US disclosed
CN-113939544-B non-core-shell polymer particles 悉尼大学 2023-08-22 CN disclosed
CN-116615468-A Polymer particles 昆士兰科技大学 2023-08-18 CN disclosed
EP-4225811-A1 POLYMER PARTICLES Queensland University Of Technology (AU) 2023-08-16 EP disclosed
WO-2023121483-A1 IMMUNOSTIMULATORY COMPOSITIONS VICTORIA LINK LIMITED (NZ) 2023-06-29 WO disclosed
WO-1992018483-A1 QUINOLINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-10-29 WO disclosed
US-5155101-A Tricyclic compounds FUJISAWA PHARMACEUTICAL COMPANY, LTD. (JP) 1992-10-13 US disclosed
EP-0498069-A2 New use of peptide derivative FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-08-12 EP disclosed
WO-1992012154-A1 IMIDAZOTRIAZINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-07-23 WO disclosed
WO-1992003438-A1 TRICYCLIC BENZODIAZEPINE DERIVATES THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-03-05 WO disclosed
WO-1992002513-A1 HETEROCYCLIC COMPOUNDS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1992-02-20 WO disclosed
US-4981847-A Tricyclic compounds FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1991-01-01 US disclosed
EP-0360079-A1 Tricyclic compounds, processes for their preparation and pharmaceutical compositions comprising them FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1990-03-28 EP disclosed
EP-0336230-A2 Cyclic peptide antagonists of Substance P and Substance K FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1989-10-11 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11834663-B2 Fibrotic treatment MMP1, ENPEP, RNPEP TDP1 3735/4885CYP1A2 4723/4885CYP2C19 4869/4885
US-20230348674-A1 HYDROGELS PHYKPL, TST, PHOSPHO1 TDP1 2333/4885CYP1A2 3550/4885CYP2C19 2661/4885
US-20240084308-A1 FIBROTIC TREATMENT MMP1, ENPEP, RNPEP TDP1 3735/4885CYP1A2 4723/4885CYP2C19 4869/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.